Subgingival Bacterial Microbiota Profile of People Living With HIV-1 Under HAART: A Systematic Review

OBJECTIVE: This systematic review aimed to assess the available literature on the subgingival bacterial microbiota profiles of PLHIV undergoing HAART. MATERIALS AND METHODS: This research was conducted in accordance with the PRISMA guidelines. Electronic searches were performed in the Cochrane Library, LILACS, PubMed, and Science Direct databases to identify primary studies evaluating the subgingival bacterial microbiota of individuals living with HIV-1 undergoing HAART. The search was performed by two independent researchers and covered the period from January 2001 to July 2022. Studies published in English, Portuguese, and Spanish were included. RESULTS: A total of 457 articles were initially retrieved. Of these, 9 met the eligibility criteria. The included studies revealed a high frequency of periodontal pathogens among individuals living with HIV-1 on HAART, including Treponema denticola (44%, nAÿ=Aÿ4 studies) and Porphyromonas gingivalis (33%, nAÿ=Aÿ3 studies), as well as species not commonly found in patients with periodontal disease, such as Enterococcus faecalis (33%, nAÿ=Aÿ2 studies). CONCLUSIONS: According to the present findings, the most frequently identified subgingival bacterial species in patients living with HIV-1 and receiving antiretroviral therapy were T. denticola and P. gingivalis, without establishing a consistent or unique microbiological profile

• Population(s)
  • General HIV+ population
• Co-infections
  • Other