SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Obstetric Nurses’ Approach to Evidence-Based Practice in Breastfeeding Within the Context of HIV: A Scoping Review

2026

BACKGROUND/OBJECTIVES: Human immunodeficiency virus remains a significant public health challenge, with breastfeeding contributing to the risk of mother-to-child transmission. Although antiretroviral therapy significantly reduces this risk, obstetric nurses face complex...

Evaluating the effectiveness of digital health interventions for HIV prevention and treatment adherence among transgender populations: A systematic review and meta-analysis

2026

BACKGROUND: Transgender individuals face a disproportionate burden of HIV due to systemic barriers including stigma, discrimination, and limited access to gender-affirming healthcare. Digital health interventions (DHIs), such as mobile applications,...

Lived experiences of cancer care for people living with HIV who are treated for anal cancer: a scoping review

2026

OBJECTIVE: This scoping review aims to identify existing evidence on the lived experiences of people living with HIV and treated for anal cancer, and to identify what aspects of health...

Doxycycline prophylaxis is effective as pre-exposure and post-exposure regimens in the prevention of sexually transmitted infections: An updated systematic review and meta-analysis

2026

BACKGROUND: Recent systematic reviews have demonstrated the efficacy of doxycycline prophylaxis in preventing bacterial sexually transmitted infections (STIs)Aÿin randomised controlled trials (RCTs). In this review, we updated evidence from RCTs...

Virological outcomes of dolutegravir-based versus other antiretroviral regimens in people living with HIV: A systematic review and meta-analysis

2026

BACKGROUND: Dolutegravir (DTG) is endorsed as a preferred option for both first- and second-line antiretroviral therapy (ART); however, comprehensive high-quality evidence regarding its virological effectiveness is still limited. This review...

The Emerging Role of Interleukin-32 in HIV-Associated Cardiovascular Comorbidities: A Mini Review

2026

With the widespread use of antiretroviral therapy (ART), the life expectancy of people living with HIV (PLWH) has significantly improved. However, the incidence of cardiovascular disease (CVD) in this population...

Incidence and predictors of opportunistic infection among people living with HIV in Ethiopia: A systematic review and meta-analysis

2026

Background Opportunistic infections (OIs) play a crucial role in the morbidity and mortality of HIV‐infected individuals. Despite the increasing use of antiretroviral therapy, there remains a lack of comprehensive data...

Knowledge of reproductive-age women about mother-to-child transmission of HIV and associated factors: A systematic review and meta-analysis

2026

INTRODUCTION: Despite significant efforts to manage and prevent HIV, knowledge gaps persist regarding mother-to-child transmission of HIV among women of reproductive age. Previous studies, limited in scope and producing inconsistent...

Rifapentine-isoniazid versus isoniazid-alone therapy for tuberculosis prevention among people living with HIV (PLHIV): a systematic review and meta-analysis of randomized trials

2026

INTRODUCTION: Tuberculosis (TB), a substantial cause of morbidity and mortality among people living with human immunodeficiency virus (PLHIV), accounted for 161,000 deaths among HIV-co-infected patients in 2023. Tuberculosis preventive therapy...

Alcohol Use and the Care Continuum for HIV Preexposure Prophylaxis: An Updated Scoping Review of Research and Interventions

2026

HIV preexposure prophylaxis (PrEP) effectiveness depends on engagement across the PrEP care continuum. Alcohol use may influence these steps, but findings remain inconsistent. This scoping review examined studies published since...

Prevalence of fungemia in people with HIV: A systematic review and meta-analysis

2026

Prior to the introduction of antiretroviral therapy (ART), people with HIV (PWH) had high risk of fungemia. No systematic review has assessed the prevalence of fungemia in PWH after the...

Closing Diagnostic Gaps in Pediatric HIV: Innovations in Point-of-Care and Digital Monitoring with an Asia-Pacific Implementation Lens-A Systematic Review

2026

Background/Objectives: Pediatric HIV case-finding and monitoring remain constrained by delayed early infant diagnosis (EID), loss to follow-up, and limited viral load (VL) testing-challenges particularly consequential in the operationally diverse Asia-Pacific...

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