SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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HIV and cardiovascular diseases: A systematic review and comparative risk assessment study

2026

Background People living with HIV (PLWH) face a significantly elevated risk of cardiovascular diseases (CVDs). This study aims to quantify temporal trends in HIV-attributable CVD burden at global, regional and...

Barriers and facilitators to the diagnosis of HIV and other STIs in primary care within publicly funded healthcare systems: A systematic review of qualitative studies

2026

BACKGROUND: Human immunodeficiency virus (HIV) and other sexually transmitted infections (STI) are a major public health concern. Primary care (PC) is the ideal setting for their diagnosis. Designing effective strategies...

Rapid diagnostic tests, laboratory-based immunoassay and nucleic acid testing strategies for long-acting injectable pre-exposure prophylaxis: A systematic review and meta-analysis

2026

Background Long-acting injectable pre-exposure prophylaxis (LAI-PrEP) is a highly effective biomedical intervention for the prevention of HIV acquisition. There is a strong interest among communities and policymakers for LAI-PrEP scale-up,...

HIV risk and prevention among cisgender men who have sex with transgender women or transfeminine nonbinary people

2026

Key take-home messages

Prevalence of cardiometabolic diseases among ART-naïve people with HIV: A global systematic review and meta-analysis

2026

Introduction The burden of cardiometabolic diseases (CMDs) is rising in people with HIV (PWH). While extensive data exist on CMD prevalence in PWH receiving antiretroviral therapy (ART), comprehensive data on...

Exclusive breastfeeding and associated factors among HIV-infected mothers in sub-Saharan African countries: A systematic review and meta-analysis

2026

Introduction The World Health Organization recommends exclusive breastfeeding for the first six months, along with maternal antiretroviral treatment, to reduce the risk of HIV transmission to infants and promote their...

Determinants of cardiovascular disease risk among LGBTQ+ populations: A systematic review of empirical evidence

2026

BACKGROUND: Understanding the multifactorial drivers of cardiovascular disease (CVD) risk in LGBTQ+ populations is critical to advancing equitable cardiovascular care. OBJECTIVE: To evaluate and synthesize empirical evidence on factors influencing...

Effects of digital health interventions to promote safer sex behaviors among youth: Systematic review and Bayesian network meta-analysis

2026

Background Youth aged 15–24 years carry a disproportionate HIV/sexually transmitted infections (STIs) burden. In recent years, different modalities of digital health interventions (DHIs) have been explored to promote safer sex behaviors...

HIV mortality surveillance in Nigeria, a systematic review of trends, determinants, and implications for public health policy

2026

Despite substantial progress in expanding antiretroviral therapy (ART) coverage and scaling up prevention interventions, Human Immunodeficiency Virus (HIV) related mortality remains a significant public health challenge in several high-burden settings,...

The gap in integrated pediatric care: A systematic review of family-based weight management for children living with HIV

2026

BACKGROUND: As children living with HIV (CWH) achieve longer life expectancy, they face an emerging ‘double burden’ of infectious and non-communicable diseases, specifically pediatric overweight and obesity (OW/OB). This risk...

Perinatal HIV in Europe: Clinical advances and psychosocial challenges—A scoping review

2026

Despite significant biomedical advances in the prevention of mother-to-child transmission (MTCT) of HIV, residual transmission and suboptimal maternal outcomes persist across Europe. The challenge is no longer primarily virological but...

Barriers and facilitators to preventing mother-to-child transmission of HIV in sub-Saharan Africa: A scoping review

2026

Women account for 59% of human immunodeficiency virus (HIV) infection cases in sub-Saharan Africa. This impacts the increase in mother-to-child HIV transmission rates and presents challenges to preventive care for...

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