SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Oral manifestations in HIV-positive individuals under highly active antiretroviral therapy: A systematic review and meta-analysis of prevalence data

2026

This study aims to analytically explore the prevalence of oral manifestations in HIV-positive patients who are receiving or are not receiving highly active antiretroviral therapy (HAART). Electronic search was conducted...

Barriers and facilitators to the diagnosis of HIV and other STIs in primary care within publicly funded healthcare systems: A systematic review of qualitative studies

2026

BACKGROUND: Human immunodeficiency virus (HIV) and other sexually transmitted infections (STI) are a major public health concern. Primary care (PC) is the ideal setting for their diagnosis. Designing effective strategies...

Rapid diagnostic tests, laboratory-based immunoassay and nucleic acid testing strategies for long-acting injectable pre-exposure prophylaxis: A systematic review and meta-analysis

2026

Background Long-acting injectable pre-exposure prophylaxis (LAI-PrEP) is a highly effective biomedical intervention for the prevention of HIV acquisition. There is a strong interest among communities and policymakers for LAI-PrEP scale-up,...

HIV risk and prevention among cisgender men who have sex with transgender women or transfeminine nonbinary people

2026

Key take-home messages

Characterisation of HIV-1 gag cytotoxic T-lymphocyte epitopes in the southern African region—A systematic review

2026

During early HIV‐1 infection, robust Cytotoxic T‐lymphocyte (CTL) responses are mostly targeted at immunodominant Gag p24 epitopes to reduce HIV‐1 viraemia to a set‐point. The aim of this study was...

Prevalence of left ventricular systolic dysfunction in HIV-infected children from sub-Saharan Africa: A systematic review and meta-analysis

2026

Background Left ventricular systolic dysfunction (LVSD) is an emerging non-communicable complication among children living with Human Immunodeficiency Virus (HIV), particularly in Sub-Saharan Africa, where paediatric HIV burden remains high. However,...

Optimising post-delivery viral load monitoring and HIV care to eliminate breastfeeding-associated HIV transmission in sub-Saharan Africa: A review

2026

Sustained maternal HIV viral-load (VL) suppression during breastfeeding is essential for eliminating vertical HIV transmission in Sub-Saharan Africa. Although vertical transmission prevention programmes have improved antiretroviral therapy coverage and peripartum...

Risk factors for HIV-associated neurocognitive impairment and frailty in aging people with HIV in Latin America: A systematic review

2026

Background As people living with HIV (PWH) in Latin America and the Caribbean (LAC) have longer life expectancy due to improved access to antiretroviral therapy (ART), complications such as HIV-associated...

HIV mortality surveillance in Nigeria, a systematic review of trends, determinants, and implications for public health policy

2026

Despite substantial progress in expanding antiretroviral therapy (ART) coverage and scaling up prevention interventions, Human Immunodeficiency Virus (HIV) related mortality remains a significant public health challenge in several high-burden settings,...

The gap in integrated pediatric care: A systematic review of family-based weight management for children living with HIV

2026

BACKGROUND: As children living with HIV (CWH) achieve longer life expectancy, they face an emerging ‘double burden’ of infectious and non-communicable diseases, specifically pediatric overweight and obesity (OW/OB). This risk...

Comparative safety of B/F/TAF versus other antiretroviral therapy regimens for treatment-experienced people with HIV-1: A systematic literature review and network meta-analysis

2026

Aim: With modern antiretroviral therapy (ART), HIV-1 has now become a manageable chronic condition. Among treatment-experienced (TE) people with HIV-1 (PWH), ART regimens can influence metabolic and renal outcomes and...

Vaccination coverage among individuals receiving HIV pre-exposure prophylaxis (PrEP): A systematic review and meta-analysis

2026

Objective: This study aimed to assess vaccination coverage among individuals receiving HIV pre-exposure prophylaxis (PrEP). Methods: A systematic review and meta-analysis were conducted following PRISMA guidelines. PubMed, Scopus, and Web of Science...

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