SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Systematic scoping review on HIV services for males in Sub-Saharan Africa: Access, barriers, and research gaps

2026

BACKGROUND: Access to HIV services among men and boys in Sub-Saharan Africa is a significant public health challenge, exacerbated by cultural norms surrounding masculinity. This scoping review systematically investigates disparities...

Surveillance of HIV-1 drug resistance in Tanzania across the pre- and post-dolutegravir eras: A systematic review and meta-analysis

2026

This systematic review and meta-analysis assessed the prevalence, mutation patterns, and factors associated with HIV drug resistance (HIVDR) in Tanzania. We searched PubMed/MEDLINE and Embase from January 1, 2006, to...

Effectiveness of differentiated antiretroviral therapy delivery models for stable persons living with HIV in Africa: A systematic review and meta-analysis

2026

Introduction: Fundamental progress has been made in HIV care, and one of the major advances was the implementation of Differentiated Service Delivery (DSD) models. DSD models are important in reducing cost...

Interventions to Improve HIV Care and Treatment Outcomes Among People with HIV Who Have Substance Use Disorder or At-Risk Substance Use: A Narrative Review

2026

Substance use adversely affects engagement in HIV care, adherence to medication, and HIV viral suppression. This review assessed the scope of US interventions designed to promote positive outcomes along the...

International guidelines for the management of healthcare workers living with HIV: a systematic comparative review

2026

BACKGROUND: Despite strong evidence that sustained HIV viral suppression eliminates transmission risk (“undetectable equals untransmittable”, U=U), national approaches to managing healthcare workers (HCWs) living with HIV remain heterogeneous. Because such...

The prognosis characteristics of HIV/HBV co-infection after antiviral therapy: A comprehensive review

2026

Co-infection of HIV and HBV is still a major global public health concern. Co-infected people have a nearly threefold increased risk of end-stage liver disease, with a noticeably faster development...

Peer network approaches for improving HIV testing, prevention and care utilisation among men in sub-Saharan Africa: A scoping review

2026

INTRODUCTION: Limited male engagement in HIV prevention and care is a global challenge more pronounced in sub-Saharan Africa (SSA) contributing to ongoing transmission. However, peer network interventions show promise in...

Global coverage of interventions for reduction of injecting drug use-related harm, HIV, viral hepatitis and tuberculosis in prisons and other carceral settings: A systematic review

2026

BACKGROUND: People who are incarcerated experience disproportionately high rates of injecting drug use and infectious disease, including HIV, viral hepatitis and tuberculosis. However, comprehensive global data regarding the availability of...

Effectiveness of Pre-exposure Prophylaxis (PrEP) in the Prevention of Human Immunodeficiency Virus (HIV): A Systematic Review of Randomized Controlled Trials With Narrative Synthesis

2026

Human immunodeficiency virus (HIV) prevention has advanced substantially, yet ending new transmissions by 2030 remains uncertain. Pre-exposure prophylaxis (PrEP) has high biological efficacy, but real-world effectiveness varies due to adherence,...

Machine Learning in HIV Care and Antiretroviral Therapy: Systematic Review

2026

BACKGROUND: Artificial intelligence (AI) is expanding across various medical fields, with machine learning (ML) being increasingly used to enhance patient management in diagnosis, prevention, and therapeutic care. OBJECTIVE: This study...

The burden of sarcopenia in people living with HIV: a systematic review and meta-analysis across WHO regions

2026

BACKGROUND: Sarcopenia, characterized by progressive loss of skeletal muscle mass and function, represents an underrecognized comorbidity in people living with human immunodeficiency virus, and comprehensive prevalence data across WHO regions...

Inflammatory Biomarkers Predicting Major Adverse Cardiovascular Events in People Living With HIV: A Systematic Review and Meta-Analysis

2026

INTRODUCTION: Chronic inflammation is a unique contributor to cardiovascular disease (CVD) risk among people living with HIV, yet there is a lack of consensus on the predictive utility of inflammatory...

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