SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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The prognosis characteristics of HIV/HBV co-infection after antiviral therapy: A comprehensive review

2026

Co-infection of HIV and HBV is still a major global public health concern. Co-infected people have a nearly threefold increased risk of end-stage liver disease, with a noticeably faster development...

Effect of BMI on mortality in patients with tuberculosis and HIV coinfection in Asia and Africa: Systematic review and meta-analysis

2026

Background Tuberculosis (TB) continues to pose a major global health threat, particularly in low- and middle-income countries. An estimated 10.8 million people developed TB in 2023, corresponding to 134 cases...

Effects of transition from paediatric to adult HIV care on virological outcomes in sub-Saharan Africa: A systematic review and meta-analysis

2026

Background: HIV remains a major global burden, with 2.4 million children and adolescents affected, 84% living in sub-Saharan Africa. As adolescents age, transitioning from paediatric to adult HIV care represents a...

Experiences and outcomes of peer navigation and support interventions for adolescents on HIV treatment in sub-Saharan Africa: A qualitative evidence synthesis

2026

Adolescents living with HIV (ALHIV) face ongoing challenges with treatment adherence and engagement in care, resulting in lower viral suppression rates compared to adults. Peer navigation has shown promise in...

The impact of HIV coinfection on Mpox patients: A systematic review and meta-analysis

2026

A substantial proportion of mpox cases occur in people with HIV, but how HIV coinfection and immune status affect clinical outcomes remains unclear. We systematically searched major databases up to...

Global prevalence and biopsychosocial correlates of psychological distress among people living with HIV: An updated theory-informed meta-analysis

2026

Introduction:  Psychological distress (PD) is common among people living with HIV (PLWH), but prevalence estimates vary substantially. This study aimed to synthesize the prevalence of PD among PLWH and examine...

The burden of HIV-related stigma on clinical and quality of life outcomes: results from a systematic literature review

2026

BACKGROUND: HIV-related stigma adversely impacts people with HIV. As part of a systematic literature review (SLR) to evaluate 6 research questions on HIV-related stigma among people with HIV, data from...

Machine learning in HIV care and antiretroviral therapy: Systematic review

2026

BACKGROUND: Artificial intelligence (AI) is expanding across various medical fields, with machine learning (ML) being increasingly used to enhance patient management in diagnosis, prevention, and therapeutic care. OBJECTIVE: This study...

Surveillance of HIV-1 drug resistance in Tanzania across the pre- and post-dolutegravir eras: A systematic review and meta-analysis

2026

This systematic review and meta-analysis assessed the prevalence, mutation patterns, and factors associated with HIV drug resistance (HIVDR) in Tanzania. We searched PubMed/MEDLINE and Embase from January 1, 2006, to...

One-year mortality among adults with advanced HIV in sub-Saharan Africa: A systematic review and meta-analysis

2026

Background: In sub-Saharan Africa (SSA), people with HIV continue to present with advanced HIV disease (AHD), putting them at high risk of life-threatening opportunistic diseases. We aimed to estimate mortality...

Incidence and predictors of mortality among adults on antiretroviral therapy in Ethiopia: A systematic review and meta-analysis

2026

BACKGROUND: Despite the United Nations’ plan to end Human Immunodeficiency Virus (HIV) as a public health concern by 2030, it remains a significant issue in low-income countries, including Ethiopia. Currently,...

HIV vulnerability among adolescent girls and young women in sub-Saharan Africa: A systematic review of individual social and structural determinants

2026

BACKGROUND: Adolescent girls and young women (AGYW) aged 15 to 24 years continue to bear a disproportionate burden of HIV infections in sub-Saharan Africa. Although substantial research has examined behavioral...

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