SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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A review of sexual transmitted infection rates among sexually assaulted patients that present for care

2022

BACKGROUND: Patients who experience sexual assault are at risk of adverse health outcomes including sexually transmitted infections (STI) and often present to various healthcare centers for post-assault care. Unfortunately, there...

The effect of perinatal HIV and antiretroviral therapy on vascular structure and function in young people: A systematic review and meta-analysis

2022

Background and aims Perinatal HIV infection (PHIV) and prolonged use of antiretroviral therapy (ART) may increase the likelihood of developing subclinical vascular dysfunction at an early age. We conducted a...

The effect of protease inhibitors-based antiretroviral therapy on serum/plasma interleukin-6 levels among PLHIV: A systematic review and meta-analysis

2022

Men who have sex with men (MSM) often change sexual behaviors following HIV diagnosis. This systematic review examined such changes, including sero-adaptive behaviors (i.e., deliberate safer-sex practices to reduce transmission...

APOBEC3, TRIM5α, and BST2 polymorphisms in healthy individuals of various populations with special references to its impact on HIV transmission

2022

AIDS restriction genes (ARGs) like APOBEC3, TRIM5α, and BST2 can act as immunological detectors of the innate protective mechanism of the body. ARGs influence the course of viral pathogenesis and...

Prevalence of human papillomavirus infection in Brazilian women living with HIV: A systematic review and meta-analysis

2022

Objective: We systematically investigated the prevalence of HPV, high-risk HPV and its genotypes in women living with human immunodeficiency virus (WLHIV) in Brazil. Methods: A systematic search was performed up to 15...

The role of innate immunity in natural elite controllers of HIV-1 infection

2022

The natural process of human immunodeficiency virus type 1(HIV-1) infection is characterized by high viral load, immune cell exhaustion, and immunodeficiency, which eventually leads to the stage of acquired immunodeficiency...

Point-of-care viral load tests to detect high HIV viral load in people living with HIV/AIDS attending health facilities

2022

Background: Viral load (VL) testing in people living with HIV (PLHIV) helps to monitor antiretroviral therapy (ART). VL is still largely tested using central laboratory-based platforms, which have long test turnaround...

COVID-19 clinical presentation among HIV-infected persons in China: A systematic review

2022

Purpose of review: The impact of HIV infection on the natural history of COVID-19 is unknown, given the recency of the human spread of SARS-CoV-2 (CoV). We reviewed published case series/reports...

Costs and cost-effectiveness of HIV early infant diagnosis in low- and middle-income countries: A scoping review

2022

BACKGROUND: Continuing progress in the global pediatric human immunodeficiency virus (HIV) response depends on timely identification and care of infants with HIV. As countries scale-out improvements to HIV early infant...

Colliding epidemics: Research gaps and implementation science opportunities for tobacco use and HIV/AIDS in low- and middle-income countries

2022

INTRODUCTION: Tobacco use is a leading cause of cancer death among people living with HIV (PLWH) worldwide, and smoking prevalence tends to be higher among PLWH. The burden of both...

The potential of telecommunication technology to address racial/ethnic disparities in HIV PrEP awareness, uptake, adherence, and persistence in care: A review

2022

Pre-exposure prophylaxis (PrEP) is highly effective in preventing new HIV infection, but uptake remains challenging among Black and Hispanic/Latino persons. The purpose of this review was to understand how studies...

Community-based ART service delivery for key populations in sub-Saharan Africa: Scoping review of outcomes along the continuum of HIV care

2022

HIV positive key population (KP) often face health system and social barriers to HIV care. KP include sex workers, men who have sex with men, persons who inject drugs, transgender...

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