Association between the interleukin-10-1082G/A, -592C/A, -819C/T gene polymorphism and HIV-1 susceptibility: A meta-analysis

The IL-10 gene polymorphism influences the pathogenesis and evolution of HIV-1 disease. Many studies in this regard have evaluated the association between this polymorphism and HIV-1 susceptibility, yet, the exact relationship between them remains ambiguous and contradictory. A systematic literature search was conducted and the found case-control studies assessing the association between the IL-10-1082G/A, -592C/A, -819C/T gene polymorphism and HIV-1 susceptibility were analyzed. The pooled odds ratios (ORs) and 95% confidence interval (CI) were calculated by a fixed effect model. In general, no significant relationship was found between the IL-10-1082G/A gene polymorphism and susceptibility to HIV-1 infection (A versus G genotype model: OR=0.97, 95% CI=0.81-1.23, P=0.775; GG versus AA+AG model: OR=0.98, 95% CI=0.76-1.27, P=0.867; GG+AG versus AA model: OR=0.97, 95% CI=0.70-1.35, P=0.852; GG versus AA model: OR=0.88, 95% CI=0.67-1.15, P=0.348; AG versus AA model: OR=0.96, 95% CI=0.67-1.37, P=0.811; GG+AA versus AG model: OR=1.03, 95% CI=0.74-1.43, P=0.886). IL-10-529C/A gene polymorphism might lead to a decreased risk of HIV-1 infection (A versus G genotype model: OR=0.88, 95% CI=0.73-1.06, P=0.166; GG versus AA+AG model: OR=0.94, 95% CI=0.80-1.11, P=0.447; GG+AG versus AA model: OR=0.75, 95% CI=0.61-0.92, P=0.005; GG versus AA model: OR=0.73, 95% CI=0.57-0.93, P=0.012; AG versus AA model: OR=0.74, 95% CI=0.60-0.92, P=0.0.007; GG+AA versus AG model: OR=1.11, 95% CI=0.72-1.71, P=0.641). IL-10-819C/T gene polymorphism might lead to an increased risk of HIV-1 infection (A versus G genotype model: OR=1.25, 95% CI=1.04-1.50, P=0.019; GG versus AA+AG model: OR=1.29, 95% CI=0.81-2.01, P=0.278; GG+AG versus AA model: OR=1.42, 95% CI=1.05-1.93, P=0.023; GG versus AA model: OR=1.63, 95% CI=1.11-2.38, P=0.012; AG versus AA model: OR=1.32, 95% CI=0.95-1.84, P=0.094; GG+AA versus AG model: OR=0.92, 95% CI=0.72-1.19, P=0.537).

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