SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Challenges to physical activity participation among older people living with HIV: Scoping review

2025

Older people living with Human Immunodeficiency Virus (OPLWH) have lower physical activity levels than other population groups. Inadequate physical activity participation increases the risks of age-related non-communicable diseases (NCDs). Therefore,...

Immunogenicity and safety of the booster COVID-19 vaccine among people with HIV: A systematic review and meta-analysis

2025

Background Human immunodeficiency virus (HIV) and COVID-19 continue to pose significant global public health challenges. Although vaccination is essential for preventing COVID-19 in people with HIV (PWH), evidence on the...

The outcomes of cryptococcal disease in HIV-positive individuals following COVID-19 infection: A systematic review and meta-analysis

2025

Background: Cryptococcal disease is considered a major cause of morbidity in individuals with HIV in resource-limited settings. The long-term effects of COVID-19 and cryptococcal coinfection among people living with HIV (PLWHIV)...

Antifungal resistance of Candida spp. isolates from HIV/AIDS patients in Iran 1999–2024: A systematic review and meta-analysis

2025

Background Antifungal resistance in Candida species in HIV/AIDS patients due to the scarcity of antifungal agents is important particularly in Iran with an estimate of 46,000 individuals living with HIV. This systematic...

Hepatitis C increases acute myocardial infarction risk in people living with HIV: A systematic review and meta-analysis

2025

BackgroundHepatitis C virus (HCV) coinfection is common among people living with HIV (PLWH) and is associated with adverse outcomes. However, the specific association between HCV coinfection and the risk of...

Artificial intelligence for HIV care: A global systematic review of current studies and emerging trends

2025

INTRODUCTION: Artificial intelligence (AI) and, in particular, machine learning (ML) have emerged as transformative tools in HIV care, driving advancements in diagnostics, treatment monitoring and patient management. The present review...

Prevalence of opportunistic bacterial infections (tuberculosis and pneumonia) among people with HIV in Ethiopia: Systematic review and meta-analysis

2025

BACKGROUND: Individuals with weakened immune systems, such as those living with Human Immunodeficiency Virus (HIV), are more vulnerable to opportunistic bacterial infections, which include tuberculosis and pneumonia. This systematic review...

Breastfeeding knowledge, attitudes and practices of HIV-positive women in Africa: A systematic review

2025

BACKGROUND: Breastfeeding is essential for ensuring the health and survival of children, particularly in regions where diarrhoea, pneumonia and malnutrition are common causes of child mortality. In sub-Saharan Africa, over...

Association between cerebrospinal fluid CXCL10 and neurocognitive disorders in people living with HIV: A meta-analysis

2025

Background C-X-C motif chemokine ligand 10 (CXCL10) is implicated in HIV-associated neuroinflammation, yet its association with HIV-associated neurocognitive disorders (HAND) remains unclear. We conducted a meta-analysis to evaluate cerebrospinal fluid...

Prevalence and resistance patterns of Mycoplasma genitalium infection in people with HIV: A systematic review and meta-analysis

2025

Objectives: This study aimed to estimate the prevalence of M. genitalium infection and understand the patterns of resistance associated mutations (resistance hereafter) in people with HIV (PWH). Methods: We searched PubMed-MEDLINE, Embase...

Seroprevalence of transfusion-transmitted infections among blood donors in India: A systematic review and meta-analysis

2025

BACKGROUND AND OBJECTIVES: Blood transfusion is essential in healthcare but carries inherent risks of human immunodeficiency virusAÿ(HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis and malaria transmission. National...

Prevalence and factors associated with HIV viral rebound in individuals on ART: A systematic review study

2025

BACKGROUND: Viral rebound (VR), the resurgence of detectable human immunodeficiency virus (HIV) viral loads (> 50 copies/mL) after suppression, remains a challenge for individuals on antiretroviral therapy (ART) in South...

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