SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Unmet need for family planning among reproductive-age women living with HIV in Africa: A systematic review and meta-analysis

2026

Background Unmet need for family planning remains a major challenge worldwide, particularly in Africa, contributing to unintended pregnancies, unsafe abortions, and increased maternal morbidity and mortality. Reducing the unmet need...

Syndemics and clinical impact of HIV and mental health conditions among people living with HIV: A systematic review and meta-analysis

2026

INTRODUCTION: People living with HIV (PLWH) may be exposed to harmful political, social, economic and environmental factors that exacerbate their risk of mental health conditions. Such factors can interact synergistically...

Alcohol use and the care continuum for HIV preexposure prophylaxis: An updated scoping review of research and interventions

2026

Rationale In 2007, WHO issued emergency recommendations on empiric treatment of sputum acid-fast bacillus (AFB) smear-negative patients with possible tuberculosis (TB) in HIV-prevalent areas, and called for operational research to...

Leveraging the barriers and facilitators of pre-exposure prophylaxis (PrEP) care among Latino men who have sex with men in the U.S. to inform intervention: A systematic literature review (2018–2023)

2026

HIV disproportionately affects Latino men who have sex with men (LMSM) in the United States (U.S.). Pre-exposure prophylaxis (PrEP) reduces HIV transmission, but prescription and use rates remain low among...

Effectiveness of empiric tuberculosis treatment for presumptive smear-negative pulmonary TB among people living with HIV, a systematic narrative review

2025

Introduction: Timely diagnosis and prompt initiation of treatment are crucial for the effective management of tuberculosis (TB), particularly in People living with HIV (PLHIV). A delay in diagnosing TB,in this special...

Experiences and outcomes of peer navigation and support interventions for adolescents on HIV treatment in sub-Saharan Africa: A qualitative evidence synthesis

2026

Adolescents living with HIV (ALHIV) face ongoing challenges with treatment adherence and engagement in care, resulting in lower viral suppression rates compared to adults. Peer navigation has shown promise in...

Effectiveness of pre-exposure prophylaxis (PrEP) in the prevention of human immunodeficiency virus (HIV): A systematic review of randomized controlled trials with narrative synthesis

2026

Human immunodeficiency virus (HIV) prevention has advanced substantially, yet ending new transmissions by 2030 remains uncertain. Pre-exposure prophylaxis (PrEP) has high biological efficacy, but real-world effectiveness varies due to adherence,...

Telomere length dynamics in adults living with HIV: A systematic review

2026

Background: HIV infection is associated with accelerated biological ageing, with telomere shortening serving as a key biomarker. Although numerous studies have investigated telomere dynamics in people living with HIV (PLWH),...

A synthesis of dimensions of wellbeing among adolescents and young people living with HIV from sub-Saharan Africa for measurement in economic evaluation: A qualitative overview of reviews

2026

Background Adolescents and young people living with HIV (AYPLHIV) in sub-Saharan Africa (SSA) face intersecting structural and psychosocial challenges that compromise their wellbeing, yet these realities are poorly captured by...

Barriers and facilitators influencing PrEP uptake among men who have sex with men and transgender women in the United States: A systematic review

2026

In the United States, men who have sex with men (MSM) and transgender women (TGW) have high HIV pre-exposure prophylaxis (PrEP) awareness, yet uptake rates remain extremely low. This signifies...

Incidence and predictors of loss to follow-up among adults on antiretroviral therapy in Ethiopia: A systematic review and meta-analysis of cohort studies

2026

Background Loss to follow-up (LTFU) from antiretroviral therapy (ART) remains a major public health concern worldwide, including in Ethiopia. However, nationally representative pooled cohort data on LTFU among adults receiving...

Youth advisory board engagement in HIV research in low- and middle-income countries: A scoping review and additional youth perspectives

2026

Background. Engaging young people (10–24 years old) in research has been shown to improve the uptake and impact of HIV interventions in youth. However, how youth are engaged in Youth...

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