SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Pharmacokinetic outcomes of the interactions of antiretroviral agents with food and supplements: A systematic review and meta-analysis

2022

Because pharmacokinetic changes in antiretroviral drugs (ARV), due to their concurrent administration with food or nutritional products, have become a clinical challenge, it is necessary to monitor the therapeutic efficacy...

HIV/AIDS post-exposure prophylaxis knowledge and uptake among health professionals in Africa: Systematic review and meta-analysis

2022

Background: Healthcare workers in developing countries are at particularly increased risk of infections from blood-borne pathogens because of the high prevalence of such pathogens in their communities as well as the...

Anal cytological abnormalities and human papillomavirus infection in women living with HIV: A systematic review and meta-analysis

2022

Objective: To provide a summary estimate of the prevalence of anal cytological abnormalities and human papillomavirus (HPV) infection as well as their covariates in women living with HIV (WLHIV). Methods: Four databases...

Interventions to improve early retention of patients in antiretroviral therapy programmes in sub-Saharan Africa: A systematic review

2022

BACKGROUND: Several interventions to improve long term retention (12 months and above) on treatment have been rigorously evaluated in Sub-Saharan Africa (SSA). However, research on interventions to improve retention of...

The association between methamphetamine use and number of sexual partners in men who have sex with men: A systematic review and meta-analysis

2022

BACKGROUND: Methamphetamine use in men who have sex with men population is significantly higher than that in the general population. Meth use can cause high-risk sexual behaviors, such as having...

Magnitude and associated factors of urinary tract infections among adults living with HIV in Ethiopia—Systematic review and meta-analysis

2022

BACKGROUND: Urinary tract infection is a major public health problem in developing countries among immunocompromized populations where there are limited health-care services. People living with human immunodeficiency virus (HIV) are...

The impact of genital ulcers on HIV transmission has been underestimated—A critical review

2022

In the early 1990s, several observational studies determined that genital ulcer disease (GUD), in either the index or the exposed person, facilitates HIV transmission. Several meta-analyses have since presented associated...

Impact of antiretroviral therapy on kidney disease in HIV infected individuals—A qualitative systematic review

2022

Kidney disease is the fourth most common cause of non-AIDS-related mortality in people living with HIV. Combination antiretroviral therapy (cART) remains the cornerstone of treatment. However, little is known about...

HIV and STI testing preferences for men who have sex with men in high-income countries: A scoping review

2022

Background: Regular testing for HIV and other sexually transmitted infections (STI) is recommended at least annually for sexually active men who have sex with men (MSM) in most high-income countries....

Adherence to pre-exposure prophylaxis in adolescents and young adults: A systematic review and meta-analysis

2022

This meta-analysis synthesized the proportion of adolescents and young adults (AYAs) who are adherent to pre-exposure prophylaxis (PrEP) and factors moderating adherence. A systematic search was conducted of studies published...

Effects of interleukin-10 -1082G/A and -592C/A gene polymorphisms on the risk of human immunodeficiency virus-1 infection: An updated meta-analysis

2022

This paper has aimed to review the available evidence on the association between Interleukin (IL) -10 -1082G/A, -592C/A gene polymorphisms and the risk of human immunodeficiency virus-1(HIV-1) infection. The data...

Discontinuation, suboptimal adherence, and reinitiation of oral HIV pre-exposure prophylaxis: A global systematic review and meta-analysis

2022

Background: Poor adherence to oral HIV pre-exposure prophylaxis (PrEP) diminishes its clinical and public health benefits. This study synthesises evidence regarding discontinuation, adherence, and reinitiation of PrEP among geographically diverse PrEP...

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