SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Magnitude and characteristics of unsuppressed HIV viral load in children and adolescents on antiretroviral therapy in sub-Saharan Africa: A systematic review and meta-analysis

2025

Background: HIV/AIDS remains a major health issue in sub-Saharan Africa, especially among children and adolescents, with a substantial proportion of people with HIV having unsuppressed viral loads despite the availability of...

Assessing the impact of digital communication tools on oral PrEP adherence: A systematic review and meta-analysis

2025

This systematic review and meta-analysis evaluated the effect of digital communication tools (e.g., text message reminders) on improving daily oral HIV pre-exposure prophylaxis (PrEP) adherence. Searching PubMed, Embase, Web of...

Better together?: A systematic review of he effectiveness of HIV prevention interventions that build or strengthen social ties

2025

Although social relationships impact health and social dynamics play a key role in shaping HIV vulnerability, results from intentional efforts to build or strengthen social relationships have not been synthesized...

Effects of test-and-treat versus preexposure prophylaxis on elimination of HIV transmission: Analysis of 24 HIV prevention trials

2025

INTRODUCTION: In 2023, 28.8 million (72%) of 39.9 million people with HIV (PWH) worldwide were on treatment with viral suppression, while 11.1 million (28%) people had viraemia with the risk...

Safer opioid supply clients’ values and preferences: A systematic review and thematic synthesis of qualitative research

2025

QUESTION: What are the values and preferences of safer opioid supply clients? STUDY SELECTION AND ANALYSIS: We conducted a systematic review of qualitative studies on safer opioid supply client experiences...

Descriptions of risks and benefits of HIV vaccine trials in low-and middle-income countries (LMICs): An integrative review

2025

Human immunodeficiency virus (HIV) vaccine trials are needed in efforts to prevent infection and acquired immunodeficiency syndrome (AIDS). Like other types of research, HIV vaccine trials present benefits and risks...

Mapping the gut microbiota composition in the context of Raltegravir, dolutegravir, and bictegravir—A scoping review

2025

(1) Background: Second-generation integrase strand transfer inhibitors (INSTIs) are now the preferred first-line therapies for human immunodeficiency virus (HIV). However, concerns regarding their side effects, such as weight gain and...

Association between baseline HIV-1 DNA levels and clinical outcomes in people living with HIV: A meta-analysis of cohort studies

2025

This systematic review and meta-analysis evaluated the effect of digital communication tools (e.g., text message reminders) on improving daily oral HIV pre-exposure prophylaxis (PrEP) adherence. Searching PubMed, Embase, Web of...

Morbidity and mortality risk among people with HIV and central or visceral adiposity: A targeted literature review

2025

BACKGROUND: Given the known relationship between human immunodeficiency virus (HIV), antiretroviral therapies, and excess visceral adipose tissue (VAT), this review sought to characterize risk of negative health outcomes associated with...

Preexposure prophylaxis and intimate partner violence among gay, bisexual, and other men who have sex with men: A global scoping review of the literature

2024

Men who have sex with men (MSM) experience intimate partner violence (IPV) and are at an elevated risk of HIV acquisition. Preexposure prophylaxis (PrEP) is an effective preventative measure against...

Extended-spectrum β-lactamase-producing Enterobacterales among people living with human immunodeficiency virus across the globe: A systematic review and meta-analysis

2025

Background People living with HIV are vulnerable to antibiotic-resistant bacterial infections because of frequent healthcare visits, the consumption of many antimicrobials, and the weakened immune system to fight infections. Our...

Prevalence of hepatitis B virus infection and its associated factors in Ethiopia: A recent systematic review and meta-analysis

2025

BACKGROUND: Hepatitis B virus (HBV) is one of the most common causes of chronic liver disease and is a growing concern in low-income countries, including Ethiopia. Different studies have been...

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