SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Global and regional molecular epidemiology of HIV-1 among men who have sex with men: A systematic review and meta-analysis

2025

Objectives The diversity of HIV-1 genotypes among Men who have sex with men (MSM) globally has changed considerably. The purpose of this study to assess the global prevalence of HIV-1...

High HIV viral suppression among adults receiving WHO-recommended first-line dolutegravir-based antiretroviral therapy in low- and middle-income countries: A systematic review and meta-analysis of programmatic evidence

2025

Background This systematic review and meta-analysis assessed viral suppression among adults receiving WHO-recommended first-line dolutegravir-based ART in programmatic settings in low- and middle-income countries (LMICs). Methods A systematic search of...

Prevalence of low-level viremia and related influencing factors among people living with HIV in China: A systematic review and meta-analysis

2025

Introduction The promotion and application of ART have significantly reduced the mortality rate of AIDS patients in China, but the problem of LLV that follows cannot be ignored. LLV is...

Effects of massage therapy on anxiety, depression, stress, pain, quality of life, and immune aspects in people living with HIV: A systematic review and meta-analysis

2025

Massage therapy has been explored as a complementary intervention for people living with HIV, with potential effects on emotional, physical, and immune system parameters. This systematic review, conducted following Preferred...

Dermatological manifestation of HIV infection: Systematic review and meta-analysis

2025

Introduction Since its discovery in 1981, AIDS has become a significant global public health issue, impacting more than 38 million people worldwide with HIV. Despite a 32% reduction in new HIV...

Advanced stage disease progression and mortality rate before and after the implementation of the Universal Test and Treat strategy (UTT) for HIV patients in Ethiopia: A systematic review and meta-analysis

2025

BACKGROUND: The universal test and treat (UTT) program, is a strategy for eliminating HIV and, it involves screening all populations at risk for HIV infection, initiating early treatment for those...

Effectiveness of tuberculosis preventive treatment on disease incidence among people living with HIV/AIDS: A systematic review and meta-analysis

2025

Background Clinical trials have shown the protective efficacy of tuberculosis preventive treatment (TPT) for averting disease and death from tuberculosis among people living with HIV/AIDS (PLHIV). TPT has been recommended...

Association between cerebrospinal fluid CXCL10 and neurocognitive disorders in people living with HIV: A meta-analysis

2025

Background C-X-C motif chemokine ligand 10 (CXCL10) is implicated in HIV-associated neuroinflammation, yet its association with HIV-associated neurocognitive disorders (HAND) remains unclear. We conducted a meta-analysis to evaluate cerebrospinal fluid...

Prevalence of opportunistic bacterial infections (tuberculosis and pneumonia) among people with HIV in Ethiopia: Systematic review and meta-analysis

2025

BACKGROUND: Individuals with weakened immune systems, such as those living with Human Immunodeficiency Virus (HIV), are more vulnerable to opportunistic bacterial infections, which include tuberculosis and pneumonia. This systematic review...

The outcomes of cryptococcal disease in HIV-positive individuals following COVID-19 infection: A systematic review and meta-analysis

2025

Background: Cryptococcal disease is considered a major cause of morbidity in individuals with HIV in resource-limited settings. The long-term effects of COVID-19 and cryptococcal coinfection among people living with HIV (PLWHIV)...

Prevalence and resistance patterns of Mycoplasma genitalium infection in people with HIV: A systematic review and meta-analysis

2025

Objectives: This study aimed to estimate the prevalence of M. genitalium infection and understand the patterns of resistance associated mutations (resistance hereafter) in people with HIV (PWH). Methods: We searched PubMed-MEDLINE, Embase...

Prevalence and factors associated with HIV viral rebound in individuals on ART: A systematic review study

2025

BACKGROUND: Viral rebound (VR), the resurgence of detectable human immunodeficiency virus (HIV) viral loads (> 50 copies/mL) after suppression, remains a challenge for individuals on antiretroviral therapy (ART) in South...

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