SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Evidence from high-income countries on the effectiveness of psychosocial interventions to improve mental health, wellbeing and quality of life for adults living with HIV: A systematic review and meta-analysis

2025

INTRODUCTION: There is a need to synthesize recent evidence on the effectiveness of psychosocial interventions to improve mental health, quality of life and wellbeing in adults living with HIV in...

Loneliness and social isolation in people with HIV

2025

PURPOSE OF REVIEW: Antiretroviral therapy (ART) has significantly extended the life expectancy of people with HIV (PWH). However, as this population ages, they face increased risk of social isolation and...

The burden of HPV infections and HPV-related diseases among people with HIV: A systematic literature review

2025

Human papillomavirus (HPV) is associated with a significant global burden of precancerous lesions and cancer. People with HIV (PWH) are at higher risk of HPV infection and HPV‐related diseases. This...

Interventions for subjective and objective social isolation among people living with HIV: A scoping review

2024

Subjective and objective social isolation has been a globally significant public health issue for people living with HIV, yet little is known about the characteristics, effectiveness, and acceptability of available...

Incidence of adverse drug reactions among HIV patients on antiretroviral drugs in Ethiopia: A systematic review and meta-analysis

2025

Introduction: In recent decades, AIDS–related illnesses have declined due to the widespread use of highly active antiretroviral therapy (HAART). Despite the numerous benefits that HAART provides, it causes significant challenges for...

Concomitant virus infection increases mortality and worsens outcome of acute pancreatitis: A systematic review and meta-analysis

2025

BACKGROUND: Acute pancreatitis (AP) is a major health threat, with a high mortality rate in severe forms. Though alcohol and bile-induced factors are the most common causes, increasing evidence suggests...

The prevalence of human papillomavirus (HPV) genotypes in the oral mucosae of HIV-positive individuals: A systematic review and meta-analysis

2025

Papillomaviruses are double-stranded DNA viruses, and it is essential to clarify their genotypic distribution for their effective prevention and clinical management. In this study, we aimed to evaluate the prevalence...

mRNA vaccines against HIV: Hopes and challenges

2025

BACKGROUND: Since the introduction of the first licensed mRNA-based vaccines against COVID-19, there has been significant interest in leveraging this technology for other vaccines. An unprecedented surge of mRNA vaccines...

A systematic review of mediation analysis frameworks in studies examining the determinants of cardiometabolic outcomes in people living with HIV

2025

Introduction Mediation analysis provides a more flexible mechanistic view of the causal relationship between HIV-related factors and cardiometabolic diseases. However, there is limited evidence on how mediation analysis is implemented...

Climate change and extreme weather events and linkages with HIV outcomes: Recent advances and ways forward

2025

PURPOSE OF REVIEW: Discuss the recent evidence on climate change and related extreme weather events (EWE) and linkages with HIV prevention and care outcomes. RECENT FINDINGS: We identified 22 studies...

HIV pre-exposure prophylaxis (PrEP) use among PrEP-eligible men who have sex with men: A systematic review and meta-analysis

2025

Objective: Scaling up pre-exposure prophylaxis (PrEP) is critical to combating the AIDS epidemic, especially among PrEP-eligible men who have sex with men (MSM). This study summarizes the global proportion of PrEP-eligible...

Retention in care after transition to adult care for adolescents and young adults with HIV: A systematic review and meta-analysis

2025

Objective: To evaluate the retention rates of adolescents and young adults (aged 10-25 years) living with HIV during the transition to adult HIV care. Methods: The study involved 15 cohort studies conducted...

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