SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Virologic Failure and Emergent Integrase Strand Transfer Inhibitor Drug Resistance With Long-Acting Cabotegravir for HIV Treatment: A Meta-analysis

2025

BACKGROUND: The long-acting injectable regimen of cabotegravir plus rilpivirine (CAB/RPV) emerged as an alternative to oral standard-of-care integrase strand transfer inhibitor (INSTI)-based regimens for individuals with adherence challenges or preference...

Cost-effectiveness of HIV prevention interventions in sub-Saharan Africa (2019-2025): A systematic review

2025

INTRODUCTION: This systematic review synthesizes recent evidence on the cost-effectiveness of HIV prevention interventions in sub-Saharan Africa (SSA), where over 70% of the global HIV burden resides. METHODS: Following PRISMA...

HIV status and the risk of typhoid fever and iNTS: A systematic review and meta-analysis

2025

OBJECTIVES: The WHO recommends prioritising people living with HIV (PLHIV) for typhoid vaccination, but evidence for increased typhoid fever risk is inconsistent. We aimed to evaluate whether HIV infection alters...

The latest trends and evolutoin of HIV medication management: A systematic review

2025

The last 10 years have witnessed various significant progresses in the management and treatment of HIV/AIDS, including the development of novel HIV prevention technologies and safer and potent antiretroviral medications....

Survival of kidney transplantation in people living with HIV/AIDS: A systematic review and meta-analysis

2025

Background The 2013 HIV Organ Policy Equity (HOPE) Act expanded kidney transplantation eligibility for people with HIV/AIDS (PWH), marking a significant milestone and necessitating updated reviews on the outcomes of...

Cost-effectiveness of HIV prevention strategies: A systematic review of economic evaluations

2025

BACKGROUND: HIV/AIDS continues to pose a significant global health challenge, especially in low- and middle-income countries. Economic evaluations are essential to identify cost-effective prevention strategies and allocate limited healthcare resources...

Rapid start with bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) as initial treatment in people with human immunodeficiency virus-1 (HIV-1): A systematic literature review of clinical and patient-reported outcomes

2025

BACKGROUND: Treatment guidelines recommend rapid antiretroviral therapy (ART) initiation among eligible people with HIV to improve treatment outcomes and reduce HIV transmission. Bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF), an integrase strand transfer inhibitor-based...

HIV and tuberculosis co-infection in non-European migrants in Europe: A systematic review and meta-analysis

2025

Background Even though HIV-TB co-infection is an emerging public health issue among migrants in European countries, the number of related articles has shown a decreasing trend. Methods To better estimate...

Effectiveness of HIV health education interventions on the MSM population: A meta-analysis

2025

Men who have sex with men (MSM) face a heightened risk of HIV, presenting a significantpublic health issue. This meta-analysis evaluates the effectiveness of HIV health educationfor MSM by examining...

Mobile health intervention tools promoting HIV pre-exposure prophylaxis among adolescent girls and young women in sub-Saharan Africa: Scoping review

2025

BACKGROUND: In 2022, 3100 adolescent girls and young women in sub-Saharan Africa experienced new HIV infections each week. HIV pre-exposure prophylaxis (PrEP) is effective at preventing HIV but has limited...

Cost-effectiveness analyses of adolescent- and young-adult-focused HIV interventions incorporating HIV transmission: A scoping review of modeling methods and proposed guidance

2025

BACKGROUND: Adolescents and young adults (AYA) are disproportionately affected by human immunodeficiency virus (HIV) globally, with high-burden population subgroups differing across regions. Cost-effectiveness modeling analyses of AYA-focused HIV interventions have...

Tetracycline-resistant Neisseria gonorrhoeae global estimates-impacts on doxycycline post-exposure prophylaxis implementation and monitoring: A systematic review

2025

Objectives Doxycycline post-exposure prophylaxis (doxyPEP) can reduce incident sexually transmitted infections including gonorrhoea for MSM and transgender women. Its effectiveness depends on the level of tetracycline resistance in Neisseria gonorrhoeae, which...

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