SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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HIV associated motor neuron disease (MND): A case series with systematic review of literature

2025

Human immunodeficiency virus (HIV) associated motor neuron disease (MND) is very rare. HIV infection can cause an MND-like syndrome due to central nervous system (CNS) involvement de novo or during...

Lipid nanoparticles in antiretroviral therapy: A nanotechnology breakthrough for HIV/AIDS treatment

2025

BACKGROUND: The development of an effective drug delivery system for the treatment of HIV/AIDS is a global challenge. The conventional drug delivery approach, namely highly active antiretroviral therapy (HAART), has...

Drug-drug interactions in transgender patients receiving antiretroviral and hormonal therapy: A systematic review of clinical studies and reports

2025

Transgender individuals, whose gender identity differs from their assigned sex at birth, often undergo pharmacotherapy, including hormone therapy (HT), as part of their gender-affirming care. This pharmacotherapy, particularly when combined...

Self-reported sleep disturbances among people living with HIV in China: A systematic review and meta-analysis

2025

Objective: People living with HIV (PLWH) commonly face a range of health issues, among which sleep disturbances are common and are related to adverse health outcomes. This review aims to assess...

Impacts of the COVID-19 pandemic on the HIV care continuum and associated factors in high-income nations: A mixed-methods systematic review

2025

The COVID-19 pandemic has significantly impacted the HIV care continuum (HCC), presenting challenges while also driving positive transformations globally. This study examines the impact of the COVID-19 pandemic on HCC...

PrEP uptake and utilisation among adolescent girls and young women in Sub-Saharan Africa: A scoping review

2025

Adolescent girls and young women (AGYW) in sub-Saharan Africa (SSA) are disproportionately affected by HIV. Despite the effectiveness of oral pre-exposure prophylaxis (PrEP) in preventing HIV, uptake and effective utilisation...

Weight gain, obesity, and the impact of lifestyle factors among people living with HIV: A systematic review

2024

HIV remains a significant health concern, but the advent of antiretroviral therapy (ART) has transformed it into a manageable chronic condition. However, weight gain and obesity pose a substantial challenge...

Invasive Neisseria meningitidis subtype C in gay, bisexual and other men who have sex with men: A systematic review

2024

INTRODUCTION: Outbreaks of invasive Neisseria meningitidis subtype C in networks of gay, bisexual and other men who have sex with men (MSM) have been reported. We aimed to explore any...

Challenges in elucidating HIV-1 genetic diversity in the Middle East and North Africa: A review based on a systematic search

2025

The extensive genetic diversity of HIV-1 represents a major challenge to public health interventions, treatment, and successful vaccine design. This challenge is particularly pronounced in the Middle East and North...

Climate change and HIV prevention: Towards sustainable solutions—A narrative review

2025

Climate change, with its pervasive environmental, social, and economic impacts, is emerging as a significant factor influencing global health outcomes, including the prevention and management of HIV. The intersection of...

Adherence definitions, measurement modalities, and psychometric properties in HIV, diabetes, and nutritional supplementation studies: A scoping review

2025

Measuring adherence has been a priority for researchers to help inform effective care for patients regularly consuming medications for chronic conditions. As a widely accepted “gold standard” adherence measure or...

Impact of HIV infection on hepatocellular carcinoma: A long-term prognostic analysis

2025

Purpose: This study aims to explore the influence of human immunodeficiency virus (HIV) infection on the prognosis of patients with hepatocellular carcinoma (HCC). Methods: According to the search strategy, we...

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