SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Nutritional status of adult people living with HIV: A narrative review

2025

BACKGROUND: The interaction between HIV infection, nutrition and immune system functioning is intricate, leading, in many cases, to a cycle of poor health outcomes. Despite the widespread use of highly...

Facilitators and barriers to Hiv pre-exposure prophylaxis adherence and retention among young men who have sex with men: A meta-ethnographic scoping review

2025

Retention and adherence to daily oral pre-exposure prophylaxis (PrEP) are critical for effective HIV prevention; however, YMSM exhibit lower rates of both compared to other populations. This is important because...

Technology-based HIV prevention interventions for men who have sex with men: Systematic review and meta-analysis

2025

BACKGROUND: There remain unmet HIV prevention needs in China, particularly among gay, bisexual, and other men who have sex with men. Technology-based interventions are increasingly used in HIV prevention worldwide....

Drug-drug interactions in transgender patients receiving antiretroviral and hormonal therapy: A systematic review of clinical studies and reports

2025

Transgender individuals, whose gender identity differs from their assigned sex at birth, often undergo pharmacotherapy, including hormone therapy (HT), as part of their gender-affirming care. This pharmacotherapy, particularly when combined...

Challenges in elucidating HIV-1 genetic diversity in the Middle East and North Africa: A review based on a systematic search

2025

The extensive genetic diversity of HIV-1 represents a major challenge to public health interventions, treatment, and successful vaccine design. This challenge is particularly pronounced in the Middle East and North...

Assessment tools for evaluating pharmacy students’ knowledge on HIV prophylaxis: A scoping review

2025

OBJECTIVES: This study aimed to identify and evaluate instruments used to measure pharmacy students’ knowledge of HIV prophylaxis, focusing on both preexposure prophylaxis (PrEP) and postexposure prophylaxis. METHODS: A systematic...

Kidney dysfunction and associated factors among adults living with human immuno-deficiency virus in Africa: A systematic review and meta-analysis

2025

Background Kidney dysfunction among adults living with Human Immuno-Deficiency Virus (HIV) increases the risk of drug-related side effects, acute kidney injury, hospitalization, and progression to end-stage kidney disease. In developing...

Impacts of the COVID-19 pandemic on the HIV care continuum and associated factors in high-income nations: A mixed-methods systematic review

2025

The COVID-19 pandemic has significantly impacted the HIV care continuum (HCC), presenting challenges while also driving positive transformations globally. This study examines the impact of the COVID-19 pandemic on HCC...

Lipid nanoparticles in antiretroviral therapy: A nanotechnology breakthrough for HIV/AIDS treatment

2025

BACKGROUND: The development of an effective drug delivery system for the treatment of HIV/AIDS is a global challenge. The conventional drug delivery approach, namely highly active antiretroviral therapy (HAART), has...

PrEP uptake and utilisation among adolescent girls and young women in Sub-Saharan Africa: A scoping review

2025

Adolescent girls and young women (AGYW) in sub-Saharan Africa (SSA) are disproportionately affected by HIV. Despite the effectiveness of oral pre-exposure prophylaxis (PrEP) in preventing HIV, uptake and effective utilisation...

Invasive Neisseria meningitidis subtype C in gay, bisexual and other men who have sex with men: A systematic review

2024

INTRODUCTION: Outbreaks of invasive Neisseria meningitidis subtype C in networks of gay, bisexual and other men who have sex with men (MSM) have been reported. We aimed to explore any...

Bridging the gap: Identifying barriers and strategies for widespread implementation of long-acting injectable antiretroviral therapy in Sub-Saharan Africa: A scoping review

2025

BACKGROUND: Long-acting injectable antiretroviral therapy (LAI ART) is a new, and innovative approach to HIV treatment, designed to address several challenges, including the adherence issues associated with daily oral ART....

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