SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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A web of risk: Multilevel factors and feedback loops (re)produce HIV ‘risk’ among gay, bisexual and other men who have sex with men—A global systematic review

2025

BACKGROUND: HIV literature shows that gay, bisexual and men who have sex with other men (GBMSM) experience inequities across social and contextual factors. Given growing inequities, this study used complex...

Incidence of severe immune-related adverse reactions in patients with HIV and cancer receiving immune checkpoint inhibitors: A systematic review and meta-analysis

2026

Background With the continuous advancement of various treatment modalities, such as antiretroviral therapy, the life expectancy of people living with HIV (PLWH) is approaching that of the general population. Consequently, the...

Systematic literature review and meta-analysis of INSTI-based antiretroviral therapy single- versus multiple-tablet regimens for the treatment of HIV

2026

Introduction Antiretroviral single-tablet regimens (STRs) have several advantages over multiple-tablet regimens (MTRs), including increased adherence and improved treatment satisfaction for people with HIV (PWH). This analysis has systematically reviewed and...

Epidemiology and safety challenges of major transfusion-transmitted pathogens in Cameroon: A systematic review and meta-analysis

2025

Objectives: This systematic review and meta-analysis (SRMA) was designed to determine the prevalence, patterns, and determinants of major transfusion-transmitted infections (TTIs), to address this gap, and to propose solutions to...

Effect of BMI on mortality in patients with tuberculosis and HIV coinfection in Asia and Africa: Systematic review and meta-analysis

2026

Background Tuberculosis (TB) continues to pose a major global health threat, particularly in low- and middle-income countries. An estimated 10.8 million people developed TB in 2023, corresponding to 134 cases...

Efficacy and safety of long-acting lenacapavir for HIV treatment and prevention: A systematic review of randomized trials

2026

Background: Lenacapavir is a first-in-class, long-acting HIV-1 capsid inhibitor enabling treatment and prevention with reduced reliance on daily oral adherence. Evidence from randomized trials across indications remains fragmented. We systematically...

A scoping review of the methods, content, and populations of rural LGBTQ health research since the new millennium

2026

INTRODUCTION: This scoping review mapped the population characteristics, methodologies, content, and publishing trends of primary research focused on rural LGBTQ individuals since the year 2000. METHODS: We conducted a search...

Missing assent: A global systematic review of ethical practices in HIV research with men who have sex with men (MSM) under 18

2026

Background Ethical safeguards are critical in HIV research involving minors, especially vulnerable groups such as men who have sex with men (MSM) under 18 years. This systematic review explores how informed...

Risk factors and mortality rates for children co-infected with HIV and TB in Ethiopia: A systematic review and meta-analysis

2025

This systematic review and meta-analysis aimed to identify risk factors and mortality rates in HIV and TB co-infected children in Ethiopia. An electronic literature search was conducted using multiple databases,...

Barriers and facilitators to the diagnosis of HIV and other STIs in primary care within publicly funded healthcare systems: A systematic review of qualitative studies

2026

BACKGROUND: Human immunodeficiency virus (HIV) and other sexually transmitted infections (STI) are a major public health concern. Primary care (PC) is the ideal setting for their diagnosis. Designing effective strategies...

HIV in Iraq: Key populations, sociodemographics, transmission modes, present realities, and urgent next steps: A systematic review

2026

Background and Purpose While empirical studies in Iraq have examined sociodemographic characteristics and modes of human immunodeficiency virus (HIV) transmission, including but not limited to those involving key populations, there...

Understanding antiretroviral therapy adherence in children with HIV: A review of barriers and strategies

2025

INTRODUCTION: Despite advancements in antiretroviral therapy (ART) availability, maintaining optimal adherence remains difficult, especially in low- and middle-income countries (LMICs). This literature review synthesized evidence on barriers and interventions influencing...

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