Burden of tuberculosis and hepatitis co-infection among people living with HIV in Nepal: A systematic review and meta-analysis

People living with HIV (PLHIV) are prone to tuberculosis (TB) and hepatitis co-infections, which cause substantial burden on morbidity and mortality. However, data on the burden of HIV co-infection from a specific low- and middle-income country are limited. To address this gap in evidence, a meta-analysis of published literature and country surveillance report was conducted to estimate the burden of TB, hepatitis B (HBV) and hepatitis C (HCV) co-infection among PLHIV in Nepal. Twenty-three studies, including 5900 PLHIV, were included in the meta-analysis. The pooled prevalence of HIV-TB, HIV-HBV and HIV-HCV co-infection was 19% (95% CI, 10–28%), 3% (2–5%) and 19% (4–33%), respectively. Low CD4 cell count (pooled odds ratio [OR] 4.38, 95% CI 1.11–17.25), smoking (3.07, 1.48–6.37) and alcohol drinking (3.12, 1.52–6.43) were significantly correlated with HIV-TB co-infection. The odds of HCV co-infection was greater in PLHIV, who were male (5.39, 1.54–18.89) and drug users (166.26, 15.94–1734.44). PLHIV who were on antiretroviral therapy had a reduced risk of HCV co-infection (0.49, 0.36–0.66) than the general PLHIV population. The burden of TB and hepatitis co-infection among PLHIV in Nepal was high. Regular screening of PLHIV for co-infections and prompt initiation of treatment are essential to reduce the transmission of infection and improve quality of life.

• Epidemiology and Determinants of Health
  • Epidemiology
  • Determinants of Health
• Determinants of Health
  • Income
• Population(s)
  • General HIV+ population
• Co-infections
  • Hepatitis B, C
  • Tuberculosis