Category Archives: Co-infections
The global epidemiology of injecting drug use, HIV, viral hepatitis and tuberculosis among people who are incarcerated: A multistage systematic review
Background: This global systematic review assesses the prevalence of injecting drug use (IDU) and key infectious diseases (HIV, hepatitis C virus [HCV], tuberculosis and hepatitis B virus [HBV]) among people...
Effectiveness of empiric tuberculosis treatment for presumptive smear-negative pulmonary TB among people living with HIV, a systematic narrative review
Introduction: Timely diagnosis and prompt initiation of treatment are crucial for the effective management of tuberculosis (TB), particularly in People living with HIV (PLHIV). A delay in diagnosing TB,in this special...
Factors influencing implementation of point-of-care tests for maternal and newborn screening and diagnosis in low-resource settings: A systematic review
BACKGROUND: Despite the potential of point-of-care (POC) tests to improve maternal and newborn health, implementation in low- and middle-income countries remains inconsistent. POC testing enables rapid, decentralized screening, but barriers...
Strategies to integrate non-communicable disease interventions in HIV and tuberculosis care contexts in low- and middle-income countries: A scoping review
INTRODUCTION: Integration of management of tuberculosis (TB) and HIV with prevention and treatment of non-communicable diseases (NCDs) is a global priority. However, delivering the full spectrum of HIV/TB and NCD...
Rifapentine-isoniazid versus isoniazid-alone therapy for tuberculosis prevention among people living with HIV (PLHIV): A systematic review and meta-analysis of randomized trials
Introduction Tuberculosis (TB), a substantial cause of morbidity and mortality among people living with human immunodeficiency virus (PLHIV), accounted for 161,000 deaths among HIV-co-infected patients in 2023. Tuberculosis preventive therapy...
Global coverage of interventions for reduction of injecting drug use-related harm, HIV, viral hepatitis and tuberculosis in prisons and other carceral settings: A systematic review
BACKGROUND: People who are incarcerated experience disproportionately high rates of injecting drug use and infectious disease, including HIV, viral hepatitis and tuberculosis. However, comprehensive global data regarding the availability of...
HIV mortality surveillance in Nigeria, a systematic review of trends, determinants, and implications for public health policy
Despite substantial progress in expanding antiretroviral therapy (ART) coverage and scaling up prevention interventions, Human Immunodeficiency Virus (HIV) related mortality remains a significant public health challenge in several high-burden settings,...
Prevalence of oral high-risk HPV and HPV16 infection among people living with HIV: A systematic review and meta-analysis
Objectives: Little is known about the natural history of oral HPV in people living with HIV (PLWH). This systematic review and meta-analysis evaluated oral HPV prevalence among PLWH. Methods: Studies with ≥18-year-old...
The impact of human immunodeficiency virus coinfection on mpox patients during the 2022 global outbreak: A systematic review and meta-analysis based on comparative observational studies
Background The mpox outbreak in 2022 posed a new challenge to the medical system. We aimed to study the impact of human immunodeficiency virus (HIV) coinfection on mpox patients. Methods This...
Virus-directed CAR immunotherapies for chronic HBV and HIV: A systematic synthesis of preclinical and early clinical evidences
BACKGROUND: Chronic hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infections are among the most important global health issues. Virus-directed CAR-T and CAR-NK are promising strategies capable of targeting...
The prevalence and influencing factors of frailty among middle-aged and older adults with HIV/AIDS from a global perspective: A systematic review and meta-analysis
Aim: Currently, frailty has become a central issue in health management among middle-aged and older people living with HIV/AIDS (PLWHA) worldwide. The objective is to develop targeted strategies to improve frailty...
Effect of BMI on mortality in patients with tuberculosis and HIV coinfection in Asia and Africa: Systematic review and meta-analysis
Background Tuberculosis (TB) continues to pose a major global health threat, particularly in low- and middle-income countries. An estimated 10.8 million people developed TB in 2023, corresponding to 134 cases...
