Category Archives: Tuberculosis
Risk factors for indeterminate interferon-gamma release assay for the diagnosis of tuberculosis in children-A systematic review and meta-analysis
Background: Interferon-gamma release assays (IGRA) are well-established immunodiagnostic tests for tuberculosis (TB) in adults. In children these tests are associated with higher rates of false-negative and indeterminate results. Age is...
The protective effect of isoniazid preventive therapy on tuberculosis incidence among HIV positive patients receiving ART in Ethiopian settings: A meta-analysis
BACKGROUND: Tuberculosis (TB) and HIV makeup a deadly synergy of infectious disease, and the combined effect is apparent in resource limited countries like Ethiopia. Previous studies have demonstrated inconsistent results...
How effective are approaches to migrant screening for infectious diseases in Europe? A systematic review
Rates of migration to Europe, and within Europe, have increased in recent years, with considerable implications for health systems. Migrants in Europe face a disproportionate burden of tuberculosis, HIV, and...
Integrated care of severe infectious diseases to people with substance use disorders; a systematic review
BACKGROUND: Various integrated care models have been used to improve treatment completion of medications for chronic hepatitis B virus (HBV), chronic hepatitis C virus (HCV), Mycobacterium tuberculosis (TB), and Human...
The burden of vaccine-preventable diseases among HIV-infected and HIV-exposed children in sub-Saharan Africa: a systematic review and meta-analysis
There are knowledge gaps regarding evidence-based research on the burden of vaccine-preventable diseases among human immunodeficiency virus (HIV)-infected and HIV-exposed children aged
Is co-location of services with HIV care associated with improved HIV care outcomes? A systematic review
This systematic review identifies models of service co-location, a structural intervention strategy to remove barriers to HIV care and services, and examines their associations with HIV care outcomes. A cumulative...
Effect of Xpert MTB/RIF on clinical outcomes in routine care settings: Individual patient data meta-analysis
BACKGROUND: Xpert MTB/RIF, the most widely used automated nucleic acid amplification test for tuberculosis, is available in more than 130 countries. Although diagnostic accuracy is well documented, anticipated improvements in...
Tuberculosis-human immunodeficiency virus (HIV) co-infection in Ethiopia: A systematic review and meta-analysis
BACKGROUND: Human Immunodeficiency Virus (HIV) and Tuberculosis (TB) are the double burden diseases of the world. The African continent takes a great share of TB-HIV cases worldwide. This study was...
Transmission of drug-resistant tuberculosis in HIV-endemic settings
The emergence and expansion of the multidrug-resistant tuberculosis epidemic is a threat to the global control of tuberculosis. Multidrug-resistant tuberculosis is the result of the selection of resistance-conferring mutations during...
Advances in the understanding of mycobacterium tuberculosis transmission in HIV-endemic settings
Tuberculosis claims more human lives than any other infectious disease. This alarming epidemic has fuelled the development of novel antimicrobials and diagnostics. However, public health interventions that interrupt transmission have...
Prevalence of extrapulmonary tuberculosis among people living with HIV/AIDS in sub-Saharan Africa: A systemic review and meta-analysis
Background: The double burden of infectious diseases such as tuberculosis (TB) and HIV disproportionately affects Africa. Our objective was to summarize the prevalence of extrapulmonary TB (EPTB) among people living...
