Category Archives: Tuberculosis
Review of human immunodeficiency virus type 1-related opportunistic infections in sub-Saharan Africa
Understanding the natural history of human immunodeficiency virus type 1 (HIV-1) and opportunistic infections in sub-Saharan Africa is necessary to optimize strategies for the prophylaxis and treatment of opportunistic infections...
Natural history of tuberculosis: Duration and fatality of untreated pulmonary tuberculosis in HIV negative patients: A systematic review
BACKGROUND: The prognosis, specifically the case fatality and duration, of untreated tuberculosis is important as many patients are not correctly diagnosed and therefore receive inadequate or no treatment. Furthermore, duration...
The effect of multiple micronutrient supplementation on mortality and morbidity of HIV-infected adults: A meta-analysis of randomized controlled trials
Numerous preclinical studies have suggested that micronutrient status is associated with the progression of human immunodeficiency virus (HIV) disease, but results from observational studies are still controversial. The objective was...
HIV prevention, treatment, and care services for people who inject drugs: A systematic review of global, regional, and national coverage
Background: Previous reviews have examined the existence of HIV prevention, treatment, and care services for injecting drug users (IDUs) worldwide, but they did not quantify the scale of coverage. We...
Interferon-y release assays for the diagnosis of tuberculosis and tuberculosis infection in HIV-infected adults: A systematic review and meta-analysis
Despite the widespread use of interferon- release assays (IGRAs), their role in diagnosing tuberculosis and targeting preventive therapy in HIV-infected patients remains unclear. We conducted a comprehensive systematic review to...
Association between the CD209 promoter -336A/G polymorphism and susceptibility to tuberculosis: A meta-analysis
Background and objective: Dendritic cell-specific intracellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN), encoded by the CD209 gene, is a major Mycobacterium tuberculosis receptor on human dendritic cells. The potentially functional -336A/G...
Short-course therapy with rifampin plus isoniazid, compared with standard therapy with isoniazid, for latent tuberculosis infection: A meta-analysis
Background. A major difficulty associated with the use of standard therapy with isoniazid for latent tuberculosis infection is poor patient adherence to therapy because of the prolonged course required. Shorter...
Human immunodeficiency virus associated tuberculosis more often due to recent infection than reactivation of latent infection
BACKGROUND: It is unclear whether human immunodeficiency virus (HIV) increases the risk of tuberculosis (TB) mainly through reactivation or following recent Mycobacterium tuberculosis (re)infection. Within a DNA fingerprint-defined cluster of...
Immune reconstitution inflammatory syndrome associated with Mycobacterium tuberculosis infection: A systematic review
HIV and tuberculosis (TB) are leading global causes of mortality and morbidity. Highly active antiretroviral therapy (HAART) is often initiated in patients being treated for TB. The immune recovery associated...
Predictive value of interferon- release assays for incident active tuberculosis: A systematic review and meta-analysis
Background: We aimed to assess whether interferon- release assays (IGRAs) can predict the development of active tuberculosis and whether the predictive ability of these tests is better than that of...
Interferon-γ release assays for active pulmonary tuberculosis diagnosis in adults in low-and middle-income countries: Systematic review and meta-analysis
Background. The diagnostic value of interferon- release assays (IGRAs) for active tuberculosis in low- and middle-income countries is unclear. Methods. We searched multiple databases for studies published through May 2010...
