Category Archives: Co-infections
Association between the CD209 promoter -336A/G polymorphism and susceptibility to tuberculosis: A meta-analysis
Background and objective: Dendritic cell-specific intracellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN), encoded by the CD209 gene, is a major Mycobacterium tuberculosis receptor on human dendritic cells. The potentially functional -336A/G...
Short-course therapy with rifampin plus isoniazid, compared with standard therapy with isoniazid, for latent tuberculosis infection: A meta-analysis
Background. A major difficulty associated with the use of standard therapy with isoniazid for latent tuberculosis infection is poor patient adherence to therapy because of the prolonged course required. Shorter...
Human immunodeficiency virus associated tuberculosis more often due to recent infection than reactivation of latent infection
BACKGROUND: It is unclear whether human immunodeficiency virus (HIV) increases the risk of tuberculosis (TB) mainly through reactivation or following recent Mycobacterium tuberculosis (re)infection. Within a DNA fingerprint-defined cluster of...
Immune reconstitution inflammatory syndrome associated with Mycobacterium tuberculosis infection: A systematic review
HIV and tuberculosis (TB) are leading global causes of mortality and morbidity. Highly active antiretroviral therapy (HAART) is often initiated in patients being treated for TB. The immune recovery associated...
Predictive value of interferon- release assays for incident active tuberculosis: A systematic review and meta-analysis
Background: We aimed to assess whether interferon- release assays (IGRAs) can predict the development of active tuberculosis and whether the predictive ability of these tests is better than that of...
Intravaginal practices, bacterial vaginosis, and women’s susceptibility to HIV infection: Epidemiological evidence and biological mechanisms
Intravaginal practices such as “dry sex” and douching have been suggested as a risk factor that may increase women’s susceptibility to HIV infection. These behaviours appear common in different populations...
Nonoxynol-9 spermicide for prevention of vaginally acquired HIV and other sexually transmitted infections: Systematic review and meta-analysis of randomised controlled trials including more than 5000 women
We aimed to determine the effectiveness of the vaginally administered spermicide nonoxynol-9 (N-9) among women for the prevention of HIV and other sexually transmitted infections (STIs). We did a systematic...
Interventions for the prevention and management of oropharyngeal candidiasis associated with HIV infection in adults and children
BACKGROUND: Oral candidiasis (OC) associated with human immunodeficiency virus (HIV) infection occurs commonly and recurs frequently, often presenting as an initial manifestation of the disease. Left untreated, these lesions contribute...
Flu and pneumococcal immunisations in HIV-infected children: Methodological quality of current recommendations
OBJECTIVE: To assess the quality of guidelines, consensus statements and systematic reviews on flu and pneumococcal immunisations in HIV-infected children. METHOD: The authors screened PubMed and Embase databases until the...
Interventions for the prevention of mycobacterium avium complex in adults and children with HIV
BACKGROUND: Mycobacterium avium complex (MAC) infection is a common complication of advanced acquired immunodeficiency syndrome (AIDS) disease and is an independent predictor of mortality and shortened survival. OBJECTIVES: To determine...
