Category Archives: Co-infections
Risk factors and mortality rates for children co-infected with HIV and TB in Ethiopia: a systematic review and meta-analysis
This systematic review and meta-analysis aimed to identify risk factors and mortality rates in HIV and TB co-infected children in Ethiopia. An electronic literature search was conducted using multiple databases,...
The risk of infection-related malignancies and tumor mutational burden in immunocompromised hosts: a systematic review and meta-analysis
BACKGROUND: Immunocompromised individuals exhibit an increased risk of malignancies attributable to impaired immune surveillance and increased susceptibility to oncogenic infections, resulting in distinct responses to immunotherapy. The intricacies of infection-related...
Epidemiology and safety challenges of major transfusion-transmitted pathogens in Cameroon: A systematic review and meta-analysis
OBJECTIVES: This systematic review and meta-analysis (SRMA) was designed to determine the prevalence, patterns, and determinants of major transfusion-transmitted infections (TTIs), to address this gap, and to propose solutions to...
Harm reduction progams and interventions for equity-deserving populations who use crack-cocaine. A scoping review
BACKGROUND: Crack-cocaine use is associated with severe physical and mental health consequences, including cardiac, pulmonary and psychiatric conditions. It also heightens the risk of overdose and transmission of infectious diseases...
Barriers and facilitators to the diagnosis of HIV and other STIs in primary care within publicly funded healthcare systems: A systematic review of qualitative studies
BACKGROUND: Human immunodeficiency virus (HIV) and other sexually transmitted infections (STI) are a major public health concern. Primary care (PC) is the ideal setting for their diagnosis. Designing effective strategies...
Age-specific distribution of cervical precancer and cancer among women living with HIV across seven countries: A systematic review and an individual patient data meta-analysis
BACKGROUND: Women living with HIV have an elevated risk for cervical cancer, present earlier, and have more recurrent human papillomavirus (HPV) infections compared with women without HIV. To update WHO...
Doxycycline prophylaxis is effective as pre-exposure and post-exposure regimens in the prevention of sexually transmitted infections: An updated systematic review and meta-analysis
BACKGROUND: Recent systematic reviews have demonstrated the efficacy of doxycycline prophylaxis in preventing bacterial sexually transmitted infections (STIs)Aÿin randomised controlled trials (RCTs). In this review, we updated evidence from RCTs...
Gender-responsive and -transformative interventions in HIV, TB and malaria programmes: A review of evidence
Gender-responsive and -transformative interventions are essential for tackling harmful social norms and discriminatory laws, policies, and practices that drive gender inequalities and health inequities especially for women, girls, and gender-diverse...
Incidence and predictors of opportunistic infection among people living with HIV in Ethiopia: A systematic review and meta-analysis
Background Opportunistic infections (OIs) play a crucial role in the morbidity and mortality of HIV‐infected individuals. Despite the increasing use of antiretroviral therapy, there remains a lack of comprehensive data...
The prognosis characteristics of HIV/HBV co-infection after antiviral therapy: A comprehensive review
Co-infection of HIV and HBV is still a major global public health concern. Co-infected people have a nearly threefold increased risk of end-stage liver disease, with a noticeably faster development...
Factors associated with severity of pulmonary tuberculosis in people living with and without HIV: A systematic review
Introduction Tuberculosis is a leading infectious cause of death and morbidity in people with and without HIV. Better identification of severe forms could help target early interventions to reduce mortality...
Systematic review and meta-analysis of respiratory virus infections in HIV-positive and HIV-negative patients
BACKGROUND: Respiratory virus infections are a major cause of morbidity and mortality globally, particularly among people living with HIV. OBJECTIVES: To evaluate the impact of respiratory virus infections on clinical...
