Category Archives: Co-infections
Harm reduction progams and interventions for equity-deserving populations who use crack-cocaine. A scoping review
BACKGROUND: Crack-cocaine use is associated with severe physical and mental health consequences, including cardiac, pulmonary and psychiatric conditions. It also heightens the risk of overdose and transmission of infectious diseases...
Barriers and facilitators to the diagnosis of HIV and other STIs in primary care within publicly funded healthcare systems: A systematic review of qualitative studies
BACKGROUND: Human immunodeficiency virus (HIV) and other sexually transmitted infections (STI) are a major public health concern. Primary care (PC) is the ideal setting for their diagnosis. Designing effective strategies...
Effect of BMI on mortality in patients with tuberculosis and HIV coinfection in Asia and Africa: Systematic review and meta-analysis
Background Tuberculosis (TB) continues to pose a major global health threat, particularly in low- and middle-income countries. An estimated 10.8 million people developed TB in 2023, corresponding to 134 cases...
Risk factors and mortality rates for children co-infected with HIV and TB in Ethiopia: A systematic review and meta-analysis
This systematic review and meta-analysis aimed to identify risk factors and mortality rates in HIV and TB co-infected children in Ethiopia. An electronic literature search was conducted using multiple databases,...
The risk of infection-related malignancies and tumor mutational burden in immunocompromised hosts: A systematic review and meta-analysis
Background Immunocompromised individuals exhibit an increased risk of malignancies attributable to impaired immune surveillance and increased susceptibility to oncogenic infections, resulting in distinct responses to immunotherapy. The intricacies of infection-related...
Doxycycline prophylaxis is effective as pre-exposure and post-exposure regimens in the prevention of sexually transmitted infections: An updated systematic review and meta-analysis
Background: Recent systematic reviews have demonstrated the efficacy of doxycycline prophylaxis in preventing bacterial sexually transmitted infections (STIs) in randomised controlled trials (RCTs). In this review, we updated evidence from RCTs...
Gender-responsive and -transformative interventions in HIV, TB and malaria programmes: A review of evidence
Gender-responsive and -transformative interventions are essential for tackling harmful social norms and discriminatory laws, policies, and practices that drive gender inequalities and health inequities especially for women, girls, and gender-diverse...
Age-specific distribution of cervical precancer and cancer among women living with HIV across seven countries: A systematic review and an individual patient data meta-analysis
Background Women living with HIV have an elevated risk for cervical cancer, present earlier, and have more recurrent human papillomavirus (HPV) infections compared with women without HIV. To update WHO recommendations...
Factors associated with severity of pulmonary tuberculosis in people living with and without HIV: A systematic review
Introduction Tuberculosis is a leading infectious cause of death and morbidity in people with and without HIV. Better identification of severe forms could help target early interventions to reduce mortality...
Incidence and predictors of opportunistic infection among people living with HIV in Ethiopia: A systematic review and meta-analysis
Background Opportunistic infections (OIs) play a crucial role in the morbidity and mortality of HIV‐infected individuals. Despite the increasing use of antiretroviral therapy, there remains a lack of comprehensive data...
The prognosis characteristics of HIV/HBV co-infection after antiviral therapy: A comprehensive review
Co-infection of HIV and HBV is still a major global public health concern. Co-infected people have a nearly threefold increased risk of end-stage liver disease, with a noticeably faster development...
Pharmacogenetics in tuberculosis-HIV coinfected populations: A systematic review of genetic variants influencing antiretroviral and anti-tuberculosis drug response
Pharmacogenetics is a concept designed to tailor medication based on genetic profile to improve efficacy and reduce adverse effects. This personalized strategy shows considerable potential for populations facing complicated therapeutic...
