Category Archives: Co-infections
The clinical outcomes of COVID-19 in HIV-positive patients: A systematic review of current evidence
INTRODUCTION: Patients with chronic underlying diseases are more susceptible to coronavirus disease 2019 (COVID-19) complications. Recent studies showed people living with HIV (PLWH) are not at greater risk than the...
Neuropsychological effects of direct-acting antiviral treatment for HCV subjects: A systematic review
Direct-acting antivirals (DAAs) have been approved in recent years to treat patients infected by the Hepatitis C virus (HCV). The DAAs treatment is well tolerated and increases sustained virological response...
Prevalence of Mycoplasma genitalium by anatomical site in men who have sex with men: A systematic review and meta-analysis
Objective: To systematically review and appraise published data, to determine the prevalence of Mycoplasma genitalium (MG) in men who have sex with men (MSM) tested at each anatomical site, that is, at...
Global estimate of phenotypic and genotypic ganciclovir resistance in cytomegalovirus infections among HIV and organ transplant patients; A systematic review and meta-analysis
Human cytomegalovirus (CMV), an opportunistic pathogen belonging to Herpesviridae family, is considered as one of the major causes of morbidity and mortality among wide variety of patients, particularly in transplant...
Prevalence and burden of HBV co-infection among people living with HIV: A global systematic review and meta-analysis
Globally, in 2017 35 million people were living with HIV (PLHIV) and 257 million had chronic HBV infection (HBsAg positive). The extent of HIV-HBsAg co-infection is unknown. We undertook a...
Antiretroviral therapy and detection of high-grade cervical intraepithelial neoplasia (CIN2+) at post-CIN management follow-up among women living with human immunodeficiency virus: A systematic review and meta-analysis
Background: We evaluated the association of antiretroviral therapy (ART), CD4+ count and human immunodeficiency virus (HIV) plasma viral load (PVL) on high-grade cervical intraepithelial neoplasia (CIN2+) detection at follow-up after CIN...
Global burden of hepatitis B Infection in people living with human immunodeficiency virus: A systematic review and meta-analysis
Background: This meta-analysis was conducted to estimate the global burden of hepatitis B virus (HBV) infection in people living with human immunodeficiency virus (PLWH). Methods: We searched multiple databases for studies published between...
Dangerous liaisons? The role of inflammation and comorbidities in HIV and SARS-CoV-2 infection
INTRODUCTION: In people living with HIV (PLWH), immune activation and inflammation levels are high even when viral suppression is maintained, potentially contributing to several comorbidities, and hampering the immune response...
Incidence and predictors of tuberculosis among HIV patients after initiation of antiretroviral treatment in Ethiopia: A systematic review and meta-analysis
BACKGROUND: Tuberculosis is the oldest infectious disease and it is still the leading cause of morbidity and mortality worldwide. Even though several primary studies have been conducted on the incidence...
Recurrent TB: a systematic review and meta-analysis of the incidence rates and the proportions of relapses and reinfections
Background: A recurrent tuberculosis (TB) episode results from exogenous reinfection or relapse after cure. The use of genotyping allows the distinction between both. Methods: We did a systematic review and meta-analysis, using four...
The prevalence of laboratory-confirmed Pneumocystis jirovecii in HIV-infected adults in Africa: A systematic review and meta-analysis
BACKGROUND: The epidemiology of Pneumocystis jirovecii, known to colonize the respiratory tract and cause a life-threatening HIV-associated pneumonia (PCP), is poorly described in Africa. We conducted a systematic review to...
