Category Archives: Co-infections

A systematic review of the incidence, risk factors and case fatality rates of invasive nontyphoidal salmonella (iNTS) disease in Africa (1966 to 2014)

2017

This study systematically reviews the literature on the occurrence, incidence and case fatality rate (CFR) of invasive nontyphoidal Salmonella (iNTS) disease in Africa from 1966 to 2014. Data on the...

Less research on tuberculosis than HIV and malaria when research agendas are poorly coordinated: A systematic review of research outputs from Cambodia

2017

OBJECTIVE: Coordination of health interventions and research is often weak during periods of political transition and unprecedented aid inflows, which Cambodia has recently experienced. Although HIV, tuberculosis (TB), and malaria...

Increased risk of group B streptococcus invasive infection in HIV-exposed but uninfected infants: A review of the evidence and possible mechanisms

2016

Group B Streptococcus (GBS) is a major cause of neonatal sepsis and mortality worldwide. Studies from both developed and developing countries have shown that HIV-exposed but uninfected (HEU) infants are...

Mortality in children diagnosed with tuberculosis: A systematic review and meta-analysis

2017

BACKGROUND: Case fatality ratios in children with tuberculosis are poorly understood-particularly those among children with HIV and children not receiving tuberculosis treatment. We did a systematic review of published work...

Clostridium difficile: A healthcare-associated infection of unknown significance in adults in sub-Saharan Africa

2016

BACKGROUND: Clostridium difficile infection (CDI) causes a high burden of disease in high-resource healthcare systems, with significant morbidity, mortality, and financial implications. CDI is a healthcare-associated infection for which the...

Association between diabetes mellitus and active tuberculosis in Africa and the effect of HIV

2017

OBJECTIVE: To determine current evidence for the association between diabetes and active tuberculosis in Africa, and how HIV modifies, or not, any association between diabetes and active tuberculosis. METHODS: We...

HIV and men

2016

INTRODUCTION: Since the initial description of HIV and AIDS, monumental efforts have been made both in the developed and developing countries to devise strategies and medications to control the disease....

Effect of secondary preventive therapy on recurrence of tuberculosis in HIV-infected individuals: A systematic review

2017

Human immunodeficiency virus (HIV)-infected individuals successfully treated for tuberculosis (TB) remain at risk of recurrence of the disease, especially in high TB incidence settings. We performed a systematic review, investigating...

Systematic review of outbreaks of Pneumocystis jirovecii pneumonia: Evidence that P. jirovecii is a transmissible organism and the implications for healthcare infection control

2016

BACKGROUND: Pneumocystis jirovecii pneumonia (PCP) is an important cause of morbidity and mortality in immunocompromised patients. Several nosocomial outbreaks of PCP have been reported in human-immunodeficiency-virus-negative, immunocompromised patients. The primary...

Depression in HIV and HCV co-infected patients: A systematic review and meta-analysis

2017

The aim of this study was to carry out a systematic review and meta-analysis of the differences in the prevalence of depression and presence of depressive symptoms between HIV/HCV co-infection,...

Prisoners co-infected with tuberculosis and HIV: A systematic review

2016

INTRODUCTION: Almost from the beginning of the HIV epidemic in 1981, an association with tuberculosis (TB) was recognized. This association between HIV and TB co-infection has been particularly evident amongst...

Seroprevalence and diagnosis of HIV, HBV, HCV and syphilis infections among blood donors

2017

BACKGROUND: Blood transfusion is one of the most important therapeutic options of life-saving intervention for recipients who are in diseased or non-diseased conditions with severe blood loss. However, it is...

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