Category Archives: Co-infections
Treatment of active tuberculosis in HIV-coinfected patients: A systematic review and meta-analysis.
Rationale: Patients with HIV-related tuberculosis (TB) have an increased risk of death, TB treatment failure, and relapse. There are several areas of uncertainty regarding the treatment of active TB in...
Interferon-gamma release assays for the diagnosis of latent tuberculosis infection in HIV-infected individuals: A systematic review and meta-analysis
Objective: To determine whether interferon-gamma release assays (IGRAs) improve the identification of HIV-infected individuals who could benefit from latent tuberculosis infection therapy. Design: Systematic review and meta-analysis. Methods: We searched...
Prevalence of tuberculosis, hepatitis C virus, and HIV in homeless people: A systematic review and meta-analysis
BACKGROUND: 100 million people worldwide are homeless; rates of mortality and morbidity are high in this population. The contribution of infectious diseases to these adverse outcomes is uncertain. Accurate estimates...
Rifampicin plus pyrazinamide versus isoniazid for treating latent tuberculosis infection: A meta-analysis
SETTING: Six trials from Haiti, Mexico, the U.S.A., Brazil, Spain, Zambia and Hong Kong. OBJECTIVE: To evaluate the efficacy and safety of rifampicin plus pyrazinamide (RZ) vs. isoniazid (INH) for...
The role of coinfections in HIV epidemic trajectory and positive prevention: A systematic review and meta-analysis
OBJECTIVES: Recurrent or persistent coinfections may increase HIV viral load and, consequently, risk of HIV transmission, thus increasing HIV incidence. We evaluated the association between malaria, herpes simplex virus type...
Effectiveness of female controlled barrier methods in preventing sexually transmitted infections and HIV: Current evidence and future research directions
OBJECTIVES: To evaluate evidence for the effectiveness of female controlled physical and chemical barrier methods in preventing STI/HIV transmission, to examine recent reviews on microbicide development, and to highlight promising...
Nonoxynol-9 for preventing vaginal acquisition of sexually transmitted infections by women from men
BACKGROUND: The incidence and prevalence of sexually transmitted infections (STI) and other reproductive tract infections (RTI) is high in much of the developing and parts of the developed worlds. STIs...
Sexually transmitted infection as a risk factor for homosexual HIV transmission: A systematic review of epidemiological studies
Existing reviews suggest some sexually transmitted infections (STIs) are risk factors in heterosexual HIV transmission. This may not be so in homosexual HIV transmission, about which reviews make no specific...
The effectiveness of pneumococcal polysaccharide vaccination in HIV-infected adults: A systematic review
OBJECTIVE: The effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV-23) in preventing pneumococcal disease in HIV-infected people is a subject of debate. We reviewed the clinical evidence for recommending PPV-23 for...
Predictors of visceral leishmaniasis relapse in HIV-infected patients: A systematic review
BACKGROUND AND OBJECTIVES: Visceral leishmaniasis (VL) is a common complication in AIDS patients living in Leishmania-endemic areas. Although antiretroviral therapy has changed the clinical course of HIV infection and its...
Young people’s knowledge, attitude, and behaviour on STI/HIV/AIDS in the context of Nepal: A systematic review
Background: Sexual and reproductive health of young people has become a major health problem in recent decades. Recent and rapidly increasing Human Immune Defi ciency Virus (HIV) rates show an...
