Category Archives: Cancer
Safety of GM-CSF in patients with AIDS: A review of the literature
We performed a literature search for all clinical studies reporting outcomes in patients with the acquired immunodeficiency syndrome (AIDS) receiving granulocyte-macrophage colony-stimulating factor (GM-CSF) for any indication. Safety outcomes included...
A review of the efficacy and outcomes studies of currently approved chemotherapy treatments for advanced AIDS-Kaposi’s sarcoma
Background: Acquired Immune Deficiency Syndrome (AIDS) – related Kaposi’s sarcoma (KS) is a rare aggressive tumor. The benefits of drug therapy are established by clinical trials but it has been...
Cancer and the ‘other’ noncommunicable chronic diseases in older people living with HIV/AIDS in resource-limited settings: A challenge to success
Objective: There is considerable research around the morbidity and mortality related to noncommunicable diseases (NCDs), particularly cardiovascular disease and diabetes, among people living with HIV/AIDS (PLWHA) in resource-richer settings. Less...
Interventions for treating AIDS-associated Hodgkin’s lymphoma in treatment-naive adults
Background: Hodgkin’s disease (HD) is the most common non-AIDS-defining malignancy in HIV-infected patients. Its unusually aggressive tumour behaviour includes a higher frequency of unfavourable histologic subtypes, high-stage and extranodal involvement...
Assessing the impact of HAART on the incidence of defining and non-defining AIDS cancers among patients with HIV/AIDS: A systematic review
After highly active antiretroviral therapy (HAART) became widespread, several studies demonstrated changes in the incidence of defining and non-defining AIDS cancers among HIV/AIDS patients. We conducted a systematic review of...
Treatment of Kaposi’s sarcoma in HIV-1 infected individuals with emphasis on resource poor settings
BACKGROUND: In many countries, Kaposi’s sarcoma (KS) is the commonest malignancy among individuals infected with the human immunodeficiency virus-1 (HIV) and is a cause of substantial morbidity and mortality. OBJECTIVES:...
Interventions for previously untreated patients with AIDS-associated Non-Hodgkin’s Lymphoma
BACKGROUND: Human immunodeficiency virus (HIV) infection is known to be associated with an increased risk of non-Hodgkin’s lymphoma (NHL). The majority of lymphomas (>80%) occurring during immunosuppression are aggressive B-cell...
Comparative incidence of cancer in HIV-AIDS patients and transplant recipients
Background: Studies have found a relationship between decreased immunity and increased incidence of cancer. Methods: A systematic review of observational studies evaluating the incidence of cancer in both organ recipients...
