Category Archives: Co-morbidities
Cardiovascular risks associated with protease inhibitors for the treatment of HIV
Introduction: Cumulative use of some first-generation protease inhibitors has been associated with higher rates of dyslipidemia and increased risk of cardiovascular disease. The protease inhibitors most commonly in use are...
Changes in body mass index among people living with HIV who are new on highly active antiretroviral therapy: A systematic review and meta-analysis
n the era of highly active antiretroviral therapy (HAART), obesity is increasingly being reported among people living with HIV (PLHIV). In this study, we reviewed published literature on body mass...
Prevalence of cardiometabolic syndrome in HIV-infected persons: A systematic review
Introduction: HIV infected persons are twofold likely to experience a heart attack, stroke, and other forms of Cardiometabolic Syndrome (CMetS). Methods: Electronic searches of databases (MEDLINE and Google Scholar) were queried for...
Is there any evidence of premature, accentuated and accelerated aging effects on neurocognition in people living with HIV? A systematic review
Despite evidence of premature, accentuated and accelerated aging for some age-related conditions such as cardiovascular diseases in people living with HIV (PLHIV), the evidence for these abnormal patterns of aging...
Impact of antiretroviral therapy on cancer treatment outcomes among people living with HIV in low- and middle-income countries: A systematic review
PURPOSE OF REVIEW: The relationship between antiretroviral therapy (ART) and cancer treatment outcomes among people living with HIV (PLWH) in low- and middle-income countries (LMICs) is complex and poorly understood...
Overweight and obesity among adult HIV infected peoples receiving ART in Ethiopia: A systematic review and meta-analysis
BACKGROUND: Over-nutrition and diet-linked non-communicable morbidities are showing increasing trend overtime. Even if there are different factors that affect the change in BMI other than ART, several authors have reported...
Antiretroviral therapy and detection of high-grade cervical intraepithelial neoplasia (CIN2+) at post-CIN management follow-up among women living with human immunodeficiency virus: A systematic review and meta-analysis
Background: We evaluated the association of antiretroviral therapy (ART), CD4+ count and human immunodeficiency virus (HIV) plasma viral load (PVL) on high-grade cervical intraepithelial neoplasia (CIN2+) detection at follow-up after CIN...
Impact of advanced HIV disease on quality of life and mortality in the era of combined antiretroviral treatment
Currently, AIDS or severe immunodeficiency remains as a challenge for people with HIV (PWHIV) and healthcare providers. Our purpose was to analyze the impact of advanced HIV disease (AHD) on...
People with HIV infection had lower bone mineral density and increased fracture risk: A meta-analysis
A meta-analysis to investigate the difference in fracture risk between individuals with and without HIV infection was performed. People living with HIV had lower bone mineral density (BMD) and greater...
Adjunct therapy for CD4(+) T-cell recovery, inflammation and immune activation in people living With HIV: A systematic review and meta-analysis
Background: HIV infection results in immune homeostasis perturbations, which is characterized by CD4(+) T-cell depletion, immune activation, and inflammation. Effective antiretroviral therapy (ART) does not fully restore immunologic and clinical...
Dangerous liaisons? The role of inflammation and comorbidities in HIV and SARS-CoV-2 infection
INTRODUCTION: In people living with HIV (PLWH), immune activation and inflammation levels are high even when viral suppression is maintained, potentially contributing to several comorbidities, and hampering the immune response...
Association of HIV infection and cognitive impairment in older adults: A meta-analysis
Objective: To synthesize evidence on the association between human immunodeficiency virus (HIV) infection and cognitive impairment in older adults. Design: Meta-analysis. Participants: Adults aged 50 years or older. Methods: In this systematic literature review and meta-analysis, we...
