Category Archives: Co-morbidities
The pathological link between elevated markers of inflammation, endothelial activation, and cardiovascular diseases in people living with HIV on combination antiretroviral therapy: A systematic review
Introduction Despite administering combination antiretroviral therapy (cART), people living with the human immunodeficiency virus (PLWH) have been identified to be at an elevated risk of cardiovascular diseases (CVDs). Notably, inflammation...
Association between HIV infection and type 2 diabetes mellitus: Global incidence, prevalence, and risk factors—A systematic review and meta-analysis
Introduction People living with HIV (PLHIV) are at an increased risk of type 2 diabetes mellitus (T2DM) due to aging, lifestyle, and antiretroviral therapy-related factors. This systematic review and meta-analysis...
Central nervous system symptoms in mpox patients without HIV co-infection: A meta-analysis
Background Co-infection with HIV in patients infected with the mpox virus (MPXV) may pose a potential risk of influencing neurological manifestations. We aimed to synthesize the central nervous system (CNS)...
Effect of human immunodeficiency virus on lung function and structure: A systematic review and meta-analysis
Rationale: Obstructive lung disease (OLD) pathogenesis includes inhalational (e.g., smoking) and noninhalational mechanisms (e.g., infections). Human immunodeficiency virus (HIV) has been suggested as a novel OLD risk factor. Substantial data...
Viral infections and risk of cardiovascular disease: Systematic review and meta-analysis
BACKGROUND: We conducted a systematic review and meta-analysis of studies examining the association of viral infections with the risk of cardiovascular disease, including coronary heart disease (CHD) and stroke. METHODS:...
Microalbuminuria among HIV/AIDS patients in Africa: A systematic review and meta-analysis
Background Over the past decade, the incidence of chronic kidney disease among HIV-seropositive people has increased at an alarming rate. Microalbuminuria is believed to be a precursor of HIV-related renal...
Exploring the impacts of high-intensity interval training (HIIT) in people living with HIV: A scoping review
People with human immunodeficiency virus (PWH) face increased health risks beyond those directly linked to HIV infection, including reduced cardiorespiratory fitness (CRF), cardiovascular disease, and accelerated aging. Physical exercise, particularly...
Syndemic interactions between HIV/AIDS, mental health conditions, and non-communicable diseases in sub-Saharan Africa: A scoping review of contributing factors
INTRODUCTION: The syndemic framework provides a critical lens for understanding the complex interplay between HIV/AIDS, mental health (MH) conditions, and non-communicable diseases (NCDs) in Africa. This scoping review explores how...
Characterization and risk stratification of coronary artery disease in people living with HIV: A global systematic review
Background Coronary artery disease (CAD) is a leading cause of mortality among people living with HIV (PLWH). Risk stratification remains inconsistent due to geographic disparities, ART-related metabolic effects, and overreliance...
Effects of massage therapy on anxiety, depression, stress, pain, quality of life, and immune aspects in people living with HIV: A systematic review and meta-analysis
Massage therapy has been explored as a complementary intervention for people living with HIV, with potential effects on emotional, physical, and immune system parameters. This systematic review, conducted following Preferred...
Non-communicable disease burden among middle-aged and older adults living with HIV in the Western Pacific region: A systematic review and meta-analysis
Objective: Middle-aged and older adults living with HIV in the Western Pacific Region (WPR) are experiencing accelerated aging and a rising burden of non-communicable disease (NCD)-related comorbidities. This systematic review and...
