Category Archives: Co-morbidities

The gap in integrated pediatric care: A systematic review of family-based weight management for children living with HIV

2026

BACKGROUND: As children living with HIV (CWH) achieve longer life expectancy, they face an emerging ‘double burden’ of infectious and non-communicable diseases, specifically pediatric overweight and obesity (OW/OB). This risk...

Lived experiences of cancer care for people living with HIV who are treated for anal cancer: A scoping review

2026

OBJECTIVE: This scoping review aims to identify existing evidence on the lived experiences of people living with HIV and treated for anal cancer, and to identify what aspects of health...

Prevalence of HIV-associated nephropathy in children: A systematic review with meta-analysis of studies published between 2004 and 2019

2026

Introduction Despite major advances in antiretroviral therapy, HIV infection remains a significant global public health challenge. HIV can directly affect the kidneys, leading to HIV-associated nephropathy in children, a condition...

HIV mortality surveillance in Nigeria, a systematic review of trends, determinants, and implications for public health policy

2026

Despite substantial progress in expanding antiretroviral therapy (ART) coverage and scaling up prevention interventions, Human Immunodeficiency Virus (HIV) related mortality remains a significant public health challenge in several high-burden settings,...

The prevalence and influencing factors of frailty among middle-aged and older adults with HIV/AIDS from a global perspective: A systematic review and meta-analysis

2026

Aim: Currently, frailty has become a central issue in health management among middle-aged and older people living with HIV/AIDS (PLWHA) worldwide. The objective is to develop targeted strategies to improve frailty...

The burden of sarcopenia in people living with HIV: A systematic review and meta-analysis across WHO regions

2026

BACKGROUND: Sarcopenia, characterized by progressive loss of skeletal muscle mass and function, represents an underrecognized comorbidity in people living with human immunodeficiency virus, and comprehensive prevalence data across WHO regions...

Incidence of severe immune-related adverse reactions in patients with HIV and cancer receiving immune checkpoint inhibitors: A systematic review and meta-analysis

2026

Background With the continuous advancement of various treatment modalities, such as antiretroviral therapy, the life expectancy of people living with HIV (PLWH) is approaching that of the general population. Consequently, the...

The risk of infection-related malignancies and tumor mutational burden in immunocompromised hosts: A systematic review and meta-analysis

2026

Background Immunocompromised individuals exhibit an increased risk of malignancies attributable to impaired immune surveillance and increased susceptibility to oncogenic infections, resulting in distinct responses to immunotherapy. The intricacies of infection-related...

Oral manifestations in HIV-positive individuals under highly active antiretroviral therapy: A systematic review and meta-analysis of prevalence data

2026

This study aims to analytically explore the prevalence of oral manifestations in HIV-positive patients who are receiving or are not receiving highly active antiretroviral therapy (HAART). Electronic search was conducted...

Polypharmacy in HIV: Rethinking what counts and why it matters

2025

Polypharmacy, the concurrent use of multiple medications, presents a growing challenge in HIV care as people living with HIV age and experience earlier onset of age-related co-morbidities. However, how polypharmacy...

Risk factors for HIV-associated neurocognitive impairment and frailty in aging people with HIV in Latin America: A systematic review

2026

Background As people living with HIV (PWH) in Latin America and the Caribbean (LAC) have longer life expectancy due to improved access to antiretroviral therapy (ART), complications such as HIV-associated...

Age-specific distribution of cervical precancer and cancer among women living with HIV across seven countries: A systematic review and an individual patient data meta-analysis

2026

Background Women living with HIV have an elevated risk for cervical cancer, present earlier, and have more recurrent human papillomavirus (HPV) infections compared with women without HIV. To update WHO recommendations...

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