Testosterone and depression: Systematic review and meta-analysis
2009
BACKGROUND: Studies suggest that testosterone (TT) replacement may have an antidepressant effect in depressed patients. OBJECTIVE: The objective of this study was to explore the effect of TT administration on...
Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa
2008
Two-thirds of the world’s HIV-infected people live in sub-Saharan Africa, and more than 1.5 million of them die annually. As access to antiretroviral treatment has expanded within the region; early...
Are treatments for cervical precancerous lesions in less-developed countries safe enough to promote scaling-up of cervical screening programs? A systematic review
2010
Background: Since the mid-1990s, there have been growing efforts to prevent cervical cancer in less-developed countries through the development of innovative screening approaches such as visual inspection of the cervix...
Adverse effects of biologics: A network meta-analysis and Cochrane overview
2011
BACKGROUND: Biologics are used for the treatment of rheumatoid arthritis and many other conditions. While the efficacy of biologics has been established, there is uncertainty regarding the adverse effects of...
Treatment of Kaposi’s sarcoma in HIV-1 infected individuals with emphasis on resource poor settings
2003
BACKGROUND: In many countries, Kaposi’s sarcoma (KS) is the commonest malignancy among individuals infected with the human immunodeficiency virus-1 (HIV) and is a cause of substantial morbidity and mortality. OBJECTIVES:...
The safety and effectiveness of statins as treatment for HIV-dyslipidemia: The evidence so far and the future challenges
2012
Introduction: Statin therapy is widely used across the globe for the treatment and prevention of cardiovascular disease (CVD). It is well established that statin therapy is associated with significant decrease...
The possible role of selenium status in adverse pregnancy outcomes
2011
The present study reviews the possible role of Se status during pregnancy regarding adverse pregnancy outcomes, with emphasis on those related to diminished antioxidant activity and increased oxidative stress. Studies...
Iron deficiency in children with HIV-associated anaemia: A systematic review and meta-analysis
2012
We conducted a systematic review and meta-analysis to determine the prevalence of iron deficiency in HIV-infected children from high- and low-income settings and compared it with that of HIV-uninfected controls....
Evaluation and management of dyslipidemia in patients with HIV infection
2002
OBJECTIVE: Persons with HIV infection develop metabolic abnormalities related to their antiretroviral therapy and HIV infection itself. The objective of this study was to summarize the emerging evidence for the...
Role of the placenta in adverse perinatal outcomes among HIV-1 seropositive women
2013
Women seropositive for human immunodeficiency virus type 1 (HIV-1) are at an increased risk for a number of adverse perinatal outcomes. Although efforts to reduce mother-to-child transmission of HIV (MTCT)...
HIV and the risk of direct obstetric complications: A systematic review and meta-analysis
2013
BACKGROUND: Women of reproductive age in parts of sub-Saharan Africa are faced both with high levels of HIV and the threat of dying from the direct complications of pregnancy. Clinicians...
Interventions for HIV-associated nephropathy
2013
BACKGROUND: Human immunodeficiency virus-associated nephropathy (HIVAN) is the most common cause of end stage kidney disease (ESKD) in human immunodeficiency virus-1 (HIV-1) serotype patients and it mostly affects patients of...
