Category Archives: Co-morbidities
Predictors and treatment strategies of HIV-related fatigue in the combined antiretroviral therapy era
Objective: To assess predictors and reported treatment strategies of HIV-related fatigue in the combined antiretroviral (cART) era. Method: Five databases were searched and reference lists of pertinent articles were checked....
HIV-associated anemia in children: A systematic review from a global perspective
Objectives:: To assess the importance of anemia in HIV-infected children in western and tropical settings. Design:: A systematic review with a descriptive component. Methods:: Four databases were searched and reference...
A review of the efficacy and outcomes studies of currently approved chemotherapy treatments for advanced AIDS-Kaposi’s sarcoma
Background: Acquired Immune Deficiency Syndrome (AIDS) – related Kaposi’s sarcoma (KS) is a rare aggressive tumor. The benefits of drug therapy are established by clinical trials but it has been...
Interventions for previously untreated patients with AIDS-associated Non-Hodgkin’s Lymphoma
BACKGROUND: Human immunodeficiency virus (HIV) infection is known to be associated with an increased risk of non-Hodgkin’s lymphoma (NHL). The majority of lymphomas (>80%) occurring during immunosuppression are aggressive B-cell...
Drug-related hypertension and resistance to antihypertensive treatment: A call for action
Several drugs can cause hypertension and/or blunt the effect of antihypertensive treatment. They can exacerbate a previously well controlled hypertension and/or render it resistant to therapy. Accordingly, drugs represent a...
Mitochondrial disorders among infants exposed to HIV and antiretroviral therapy
Although antiretroviral therapy (ART) is critical for preventing mother-to-child transmission of HIV, concern has been raised about the possibility that it may cause mitochondrial dysfunction in infants. There is adequate...
Anabolic steroids for the treatment of weight loss in HIV-infected individuals
BACKGROUND: Individuals with HIV infection often lose weight during the course of their disease. Furthermore, low serum concentrations of testosterone are common in individuals with HIV infection, particularly those with...
Influence of human immunodeficiency virus infection on the course of hepatitis C virus infection: A meta-analysis
Studies have shown that rates of liver disease are higher in persons who are coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) than they are in persons...
Pharmacological treatment of painful HIV-associated sensory neuropathy: A systematic review and meta-analysis of randomised controlled trials
BACKGROUND: Significant pain from HIV-associated sensory neuropathy (HIV-SN) affects ~40% of HIV infected individuals treated with antiretroviral therapy (ART). The prevalence of HIV-SN has increased despite the more widespread use...
Incident fractures in HIV-infected individuals: A systematic review and meta-analysis
OBJECTIVE(S): Some but not all studies indicate that individuals with HIV infection are at an increased risk of fracture. We systematically reviewed the literature to investigate whether incidence of fracture...
The impact of hepatitis C virus coinfection on HIV-related kidney disease: A systematic review and meta-analysis
BACKGROUND: In the era of antiretroviral therapy, non-AIDS complications such as kidney disease are important contributors to morbidity and mortality. OBJECTIVE: To estimate the impact of hepatitis C coinfection on...