Category Archives: Co-morbidities
Protease inhibitors and avascular necrosis: A systematic review and meta-analysis
Avascular necrosis (AVN) is a pathological process associated with many medical conditions, including human immunodeficiency virus (HIV) infection. Whether or not the use of protease inhibitors (PIs) confers additional risk...
Isoniazid prophylaxis for tuberculosis in HIV infection: A meta-analysis of randomized controlled trials
OBJECTIVES: To evaluate the efficacy of isoniazid for the prevention of tuberculosis in tuberculin skin test-positive and negative individuals with HIV infection. DESIGN: Meta-analysis of randomized controlled trials. SETTING: Seven...
A review of anti-D treatment of childhood idiopathic thrombocytopenic purpura
Treatment of childhood idiopathic thrombocytopenic purpura is still an area of controversy. We reviewed the literature on anti-D treatment. Most studies used intravenous anti-D. Single doses of 50 microg/kg increased...
Effectiveness and cost-effectiveness of home palliative care services for adults with advanced illness and their caregivers
Background: Extensive evidence shows that well over 50% of people prefer to be cared for and to die at home provided circumstances allow choice. Despite best efforts and policies, one-third...
Treatment of acute cryptococcal meningitis in HIV infected adults, with an emphasis on resource-limited settings
BACKGROUND: Despite the advent and increasingly wide availability of antiretroviral therapy, cryptococcal meningitis (CM) remains a significant cause of mortality and morbidity amongst individuals with HIV infection in resource-limited settings....
Relative risk of cardiovascular disease among people living with HIV: A systematic review and meta-analysis
OBJECTIVES: The aim of this study was to estimate the relative risk of cardiovascular disease (CVD) among people living with HIV (PLHIV) compared with the HIV-uninfected population. METHODS: We conducted...
Is chronic HIV infection associated with venous thrombotic disease? A systematic review
Infection with the human immunodeficiency virus (HIV) is still a major health problem world-wide. HIV infection has changed into a chronic infection with the chance of developing long-term complications. Vascular...
The validity of the modification of diet in renal disease formula in HIV-infected patients: A systematic review
RATIONALE, AIMS AND OBJECTIVES: Renal dysfunction is highly prevalent in HIV-infected patients and may require dose adjustment of renally excreted antiretroviral drugs. The Modification of Diet in Renal Disease (MDRD)-4...
Risk of melanoma in people with HIV/AIDS in the pre- and post-HAART eras: A systematic review and meta-analysis of cohort studies
OBJECTIVE: Following the introduction of highly active antiretroviral therapy (HAART) the risk of AIDS-defining cancers decreased but incidence of many non-AIDS-defining cancers has reportedly increased in those with HIV/AIDS. Whether...
The effect of multiple micronutrient supplementation on mortality and morbidity of HIV-infected adults: A meta-analysis of randomized controlled trials
Numerous preclinical studies have suggested that micronutrient status is associated with the progression of human immunodeficiency virus (HIV) disease, but results from observational studies are still controversial. The objective was...
