Category Archives: Co-morbidities
Association between protease inhibitor use and increased cardiovascular risk in patients infected with human immunodeficiency virus: A systematic review
Some studies have shown that currently available protease inhibitors (PIs) are associated with an increased risk of cardiovascular disease. We have systematically reviewed the published literature and conference abstracts for...
Placebo response changes depending on the neuropathic pain syndrome: Results of a systematic review and meta-analysis
Objective. To compare placebo responses in neuropathic pain syndromes. Design. Systematic literature review and meta-analysis. Setting and Patients. Randomized placebo-controlled trials assessing pain intensity or pain relief in any neuropathic...
Causal inference regarding infectious aetiology of chronic conditions: A systematic review
Background: Current guidelines recommend screening all people living with human immunodeficiency virus (PLHIV) who have a CD4 count ≤100 cells/µL for cryptococcal antigen (CrAg) to identify those patients who could benefit...
Hormonal contraception decreases bacterial vaginosis but oral contraception may increase candidiasis: Implications for HIV transmission
OBJECTIVE: A 2012 WHO consultation concluded that combined oral contraception (COC) does not increase HIV acquisition in women, but the evidence for depot medroxyprogesterone acetate (DMPA) is conflicting. We evaluated...
The effects of exercise training on metabolic and morphological outcomes for people living with HIV: A systematic review of randomised controlled trials
PURPOSE: to determine the effects of exercise on metabolic and morphological outcomes among people with HIV using a systematic search strategy of randomized, controlled trials (RCTs). METHODS: two independent reviewers...
Risk of cardiovascular disease from antiretroviral therapy for HIV: A systematic review
BACKGROUND: Recent studies suggest certain antiretroviral therapy (ART) drugs are associated with increases in cardiovascular disease. PURPOSE: We performed a systematic review and meta-analysis to summarize the available evidence, with...
HIV prevalence and mortality among children undergoing treatment for severe acute malnutrition in sub-Saharan Africa: A systematic review and meta-analysis
This systematic review and meta-analysis explored HIV prevalence and mortality in children undergoing treatment for severe acute malnutrition (SAM) in sub-Saharan Africa. It included all studies reporting on HIV infection...
The efficacy and safety of insulin-sensitizing drugs in HIV-associated lipodystrophy syndrome: A meta-analysis of randomized trials
BACKGROUND:HIV-associated lipodystrophy syndrome (HALS) is characterized by insulin resistance, abnormal lipid metabolism and redistribution of body fat. To date, there has been no quantitative summary of the effects of insulin...
Epidemiology and prevention of human papillomavirus and cervical cancer in sub-Saharan Africa: A comprehensive review
OBJECTIVES: To identify the gaps of knowledge and highlight the challenges and opportunities for controlling cervical cancer in sub-Saharan Africa (SSA). METHODS: A comprehensive review of peer-reviewed literature to summarize...
