Category Archives: Epidemiology

A systematic review on the meaning of the concept ‘AIDS Orphan’: Confusion over definitions and implications for care

2008

Global publications on the international AIDS epidemic report on the existence of an ever-increasing number of orphans and vulnerable children. It has been suggested that by the end of this...

Accuracy of serological assays for detection of recent infection with HIV and estimation of population incidence: A systematic review

2009

We systematically reviewed the accuracy of serological tests for recent infections with HIV that have become widely used for measuring population patterns incidence of HIV. Across 13 different assays, sensitivity...

Systematic review of HIV and HCV infection among drug users in China

2009

To determine the HIV and hepatitis C virus (HCV) geographical distribution among drug users in China, a systematic literature review of 40 peer-reviewed publications (comprising 15,565 drug users) was conducted....

Therapeutic drug monitoring of antiretrovirals for people with HIV

2006

BACKGROUND: Despite the efficacy of combination antiretroviral therapy (ART) and the improvement in prognosis of those living with HIV/AIDS, a large proportion of individuals on ART does not achieve or...

Mathematical models for the study of HIV spread and control amongst men who have sex with men

2011

For a quarter of century, mathematical models have been used to study the spread and control of HIV amongst men who have sex with men (MSM). We searched MEDLINE and...

A decline in HIV and syphilis epidemics in Chinese female sex workers (2000-2011): A systematic review and meta-analysis

2013

BACKGROUND: Female sex workers (FSWs) play an important role in transmitting HIV and syphilis from high-risk groups to the general population. However, the trends in HIV and syphilis epidemics in...

Geographical representativeness of published and ongoing randomized controlled trials. The example of: Tobacco consumption and HIV infection

2011

Background: The challenge for evidence-based healthcare is to reduce mortality and the burden of diseases. This study aimed to compare where research is conducted to where research is needed for...

Assessing tuberculosis case fatality ratio: A meta-analysis

2011

BACKGROUND: Recently, the tuberculosis (TB) Task Force Impact Measurement acknowledged the need to review the assumptions underlying the TB mortality estimates published annually by the World Health Organization (WHO). TB...

Genital ulcer disease treatment for reducing sexual acquisition of HIV

2012

BACKGROUND: Genital ulcer disease by virtue of disruption of the mucosal surfaces may enhance HIV acquisition. Genital ulcer disease treatment with resolution of the ulcers may therefore contribute in reducing...

Risk of window period hepatitis-C infection in high infectious risk donors: Systematic review and meta-analysis

2011

The OPTN classifies high infectious risk donors (HRDs) based on criteria originally intended to identify people at risk for HIV infection. These donors are sometimes referred to as ‘CDC high...

What has been achieved in HIV prevention, treatment and care for people who inject drugs, 2010-2012? A review of the six highest burden countries

2014

OBJECTIVE: In 2010 the international HIV/AIDS community called on countries to take action to prevent HIV transmission among people who inject drugs (PWID). To set a baseline we proposed an...

Prevalence of tuberculosis, hepatitis C virus, and HIV in homeless people: A systematic review and meta-analysis

2012

BACKGROUND: 100 million people worldwide are homeless; rates of mortality and morbidity are high in this population. The contribution of infectious diseases to these adverse outcomes is uncertain. Accurate estimates...

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