Category Archives: Epidemiology and Determinants of Health
Safety and efficacy of long-acting injectable agents for HIV-1: Systematic review and meta-analysis
Background: HIV-1 infection continues to affect global health. Although antiretrovirals can reduce the viral load or prevent HIV-1 infection, current drugs require daily oral use with a high adherence level. Long-acting...
A systematic review and meta-analysis of the prevalence of triplex infections (combined Human Immunodeficiency Virus, hepatitis B Virus, and hepatitis C Virus) among pregnant women in Nigeria
OBJECTIVE: We systematically identified the prevalence of triplex infections (combined human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV)) in pregnancy. METHODS: To gather information on...
Virtual avatars as a new tool for human immunodeficiency virus prevention among men who have sex with men: A narrative review
BACKGROUND AND OBJECTIVE: Human immunodeficiency virus (HIV) continues to affect sexual and gender minorities, predominantly men who have sex with men (MSM). Stigma, medical mistrust, and apprehension towards discussing sexual...
Adverse perinatal outcomes attributable to HIV in sub-Saharan Africa from 1990 to 2020: Systematic review and meta-analyses
Background: Maternal HIV infection and antiretroviral drugs (ARVs) are associated with increased risks of adverse perinatal outcomes. The vast majority of pregnant women living with HIV (WLHIV) reside in sub-Saharan Africa....
Global and regional estimate of HIV-associated stroke burden: A meta-analysis and population attributable modeling study
Background: This study aimed to determine the correlation between human-immunodeficiency-virus (HIV) infection and stroke, as well as to estimate the global, regional, and national burden of HIV-associated stroke. Methods: A registered meta-analysis...
Association between integrase strand transfer inhibitor use with insulin resistance and incident diabetes mellitus in persons living with HIV: A systematic review and meta-analysis
Whether integrase strand transfer inhibitors (INSTIs) are associated with a higher risk of incident type 2 diabetes mellitus (DM) than other antiretroviral therapies (ART) needs to be established. MEDLINE, Embase,...
Pharmacotherapeutic interventions in people living with HIV undergoing solid organ transplantation: A scoping review
The pharmacotherapeutic management of people living with HIV (PLWHIV) undergoing solid organ transplantation (SOT) is clinically challenging, mainly due to the frequent occurrence of complex drug-drug interactions. Although various strategies...
Epidemiologic evidence on the role of Lactobacillus iners in sexually transmitted infections and bacterial vaginosis: A series of systematic reviews and meta-analyses
Although Lactobacillus crispatus -dominated vaginal microbiotas are thought to protect against bacterial vaginosis (BV) and sexually transmitted infections, the role of Lactobacillus iners -dominated microbiotas is less clear. To better...
Association of apolipoprotein E epsilon 4 and cognitive impairment in adults living with human immunodeficiency virus: A meta-analysis
Background: It is controversial whether the apolipoprotein E epsilon 4 allele (APOE ε4) is a risk gene for human immunodeficiency virus (HIV)-related neurocognitive impairment. This meta-analysis aimed to summarize evidence of...
Adult HIV-1 incidence across 15 high-burden countries in sub-Saharan Africa from 2015 to 2019: A pooled analysis of nationally representative data
Background Harmonised population-based surveys with recent HIV-1 infection testing algorithms permit pooled cross-sectional estimation of HIV incidence across multiple countries. We aimed to estimate adult HIV-1 incidence rates and number...
The burden of chlamydia, gonorrhea, and syphilis in older adults in the United States: A systematic review
BACKGROUND: Increases in life expectancy, the availability of sexual performance enhancing medication, and changes in sexual partnering suggest that sexually transmitted infections (STIs) among older persons could be on the...
