Category Archives: Neurocognitive disorders

Association of apolipoprotein E epsilon 4 and cognitive impairment in adults living with human immunodeficiency virus: A meta-analysis

2023

Background: It is controversial whether the apolipoprotein E epsilon 4 allele (APOE ε4) is a risk gene for human immunodeficiency virus (HIV)-related neurocognitive impairment. This meta-analysis aimed to summarize evidence of...

Neurocognitive impairment and associated factors among people living with HIV: A systematic review and meta-analysis of African studies

2023

BACKGROUND: Neurocognitive impairment (NCI) is one of the most common neurological complications in HIV-positive individuals, particularly in resource-limited countries. Neurocognitive impairments can occur at any stage of HIV infection, although...

Reporting individual-level research results from neurocognitive and psychological research in people living with HIV: Lessons from dementia research

2023

PURPOSE OF REVIEW: There are growing expectations for the return of individual-level research results (RoR), which promotes autonomy and potential clinical and personal benefits. There are ethical and practical challenges,...

The global burden of cognitive impairment in people with HIV

2023

OBJECTIVE: While life expectancies of people with HIV (PWH) have increased through the successes of antiretroviral treatment, cognitive impairment remains a pressing concern. Prevalence estimates vary worldwide as different definitions...

Altered white matter integrity in the corpus callosum in adults with HIV: A systematic review of diffusion tensor imaging studies

2022

We systematically reviewed studies comparing differences in the integrity of the corpus callosum in adults with HIV compared to healthy controls, using Diffusion Tensor Imaging (DTI), using search engines Science...

The global burden of cognitive impairment in people living with HIV: A systematic review and meta-analysis

2022

Objective: While life expectancies of people with HIV (PWH) have increased through the successes of antiretroviral treatment, cognitive impairment remains a pressing concern. Prevalence estimates vary worldwide as different definitions for...

Epstein-Barr virus detection in the central nervous system of HIV-infected patients

2022

Simply detecting Epstein-Barr virus deoxyribonucleic acid (EBV-DNA) is insufficient to diagnose EBV-associated diseases. The current literature around EBV-DNA detection from cerebrospinal fluid (CSF) in human immunodeficiency virus (HIV)-positive non-lymphoma patients...

HIV antiretroviral medication neuropenetrance and neurocognitive outcomes in HIV+ adults: A review of the literature examining the central nervous system penetration effectiveness score

2022

This literature review summarizes the existing research examining the CNS penetration effectiveness (CPE) score and neurocognitive outcomes (i.e., neuropsychological assessment and neurocognitive screening) in HIV+ individuals. Despite the effectiveness of...

The effect of antiretroviral therapy with high central nervous system penetration on HIV-related cognitive impairment: A systematic review and meta-analysis

2022

Chronic complications are a significant concern for people living with HIV/AIDS (PLWHA) infection. HIV-associated neurocognitive disorders (HAND) are prevalent in PLWHA. Yet, the efficacy of medications that penetrate the central...

HIV dementia: A bibliometric analysis and brief review of the top 100 cited articles

2022

Dementia is a syndrome of cognitive impairment that affects an individual’s ability to live independently. The number of people living with dementia worldwide in 2015 was estimated at 47.47 million....

Worldwide occurrence of HIV-associated neurocognitive disorders and its associated factors: A systematic review and meta-analysis

2022

BACKGROUND: HIV-associated neurocognitive disorders are common in people living with HIV/AIDS and affect the adherence of patients to prescriptions, activities of daily living, and quality of life of patients. However,...

Central nervous system and neurodevelopmental outcomes of HIV + and HIV exposed children: A mini review of recent findings and lessons learned from the field

2022

There has been an increase in research looking at neurodevelopmental/neurologic outcomes of children living with HIV (Children LWHIV) and HIV exposed but uninfected children (HEU) during an era of ART....

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