Category Archives: Neurocognitive disorders

The electrophysiology of neuroHIV: A systematic review of EEG and MEG studies in people with HIV infection since the advent of highly-active antiretroviral therapy

2017

OBJECTIVE: The Human Immunodeficiency Virus (HIV) has an impact on the brain, even when the infection is well-controlled with modern highly-active antiretroviral therapy (HAART). While dementia is rare in those...

PET brain imaging in HIV-associated neurocognitive disorders (HAND) in the era of combination antiretroviral therapy

2017

Effective combination antiretroviral therapy (cART) has lead to a significant reduction in the prevalence and incidence of central nervous system (CNS) HIV-associated brain disease, particularly CNS opportunistic infections and HIV...

HIV-associated cognitive impairment in perinatally infected children: A meta-analysis

2016

CONTEXT: Research shows, conclusively, that perinatal HIV infection has negative effects on cognitive functioning of children and adolescents. However, the extent of these cognitive impairments is unknown. Current literature does...

A review of trials investigating efavirenz-induced neuropsychiatric side effects and the implications

2016

Efavirenz is part of the first-line treatment for HIV patients including those in South Africa with approximately 50% experiencing neuropsychiatric side effects. A systematic review of papers reporting neuropsychiatric side...

Cognitive impairment in HIV and HCV co-infected patients: A systematic review and meta-analysis

2016

Cognitive impairment has been well documented in human immunodeficiency virus (HIV) and hepatitis C virus (HCV) mono-infections. However, in the context of HIV/HCV co-infection the research is more limited. The...

Review of functional MRI in HIV: Effects of aging and medication

2016

HIV-associated neurocognitive disorder (HAND) is a frequently occurring comorbidity of HIV infection. Evidence suggests this condition starts subclinical before a progression to a symptomatic stage. Blood oxygenated level dependent (BOLD)...

The mental health of people living with HIV in China, 1998-2014: A systematic review

2016

BACKGROUND: Understanding the mental health burdens faced by people living with HIV in China is instrumental in the development of successful targeted programs for psychological support and care. METHODS: Using...

The influence of neurocognitive impairment on HIV risk behaviors and intervention outcomes among high-risk substance users: A systematic review

2016

Neurocognitive impairment (NCI) among high-risk substance users poses a substantial barrier to reducing risk behaviors in this population. Previous work suggests that NCI is intertwined in a close, reciprocal relationship...

Differential genotypic evolution of HIV-1 quasispecies in cerebrospinal fluid and plasma: A systematic review

2013

HIV-1 enters the central nervous system by passing the blood-brain barrier during primary infection. Despite the introduction of combination antiretroviral therapy, the prevalence of HIV-associated neurocognitive disorders remains high and...

The relationship between HIV and prevalence of disabilities in sub-Saharan Africa: Systematic review

2015

OBJECTIVE: To systematically review evidence on the prevalence and risk of disabilities among children and adults living with HIV in sub-Saharan Africa. METHODS: Articles were identified from 1980 to June...

Psychosocial, mental health, and behavioral issues of aging with HIV

2014

PURPOSE OF REVIEW: People with HIV continue to live with the health consequences of an episodic illness that limits their ability to fully participate in society, particularly for the growing...

Systematic review of neuroimaging studies in vertically transmitted HIV positive children and adolescents

2014

One of the most serious consequences of vertical HIV-infection is its impact on the central nervous system (CNS). Although much work has been done to elucidate the complex mechanism of...

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