Category Archives: Neurocognitive disorders
The relationship between potentially traumatic or stressful events, HIV infection and neurocognitive impairment (NCI): A systematic review of observational epidemiological studies
BACKGROUND: HIV/AIDS and potentially traumatic events (PTEs) or stressful life events (SLEs) and/or PTSD are independently associated with neurocognitive impairment (NCI). Literature suggests that HIV and PTE/SLE exposure independently and...
Antiretroviral therapy improves neurocognitive impairment in people living with HIV? A meta-analysis
Objectives: Although effective antiretroviral therapy (ART) has been used for more than two decades, HIV-associated neurocognitive disorder remains prevalent. Thus, whether ART can improve neurocognitive impairment is controversial. This review...
Peripheral immune dysregulation in the ART era of HIV-associated neurocognitive impairments: A systematic review
Human immunodeficiency virus-associated neurocognitive impairment (HANI) remains problematic despite the effective use of antiretroviral therapy (ART) and viral suppression. A dysregulated immune response contributes to the development of HANI but...
Screening tools for HIV-associated neurocognitive disorders among adults living with HIV in sub-Saharan Africa: A scoping review
Background: People living with HIV are at risk of developing HIV-associated neurocognitive disorders (HAND) which adversely affects their quality of life. Routine screening of HAND in HIV care is recommended...
Pharmacologic and non-pharmacologic interventions for HIV-neuropathy pain. A systematic review and a meta-analysis
Background and Objectives: Among HIV infection symptoms, sensory neuropathy (HIV-SN) remains a main cause of suffering, with incidence varying from 13-50%. So far, numerous pharmacological and non-pharmacological treatments have been...
The association of memory disorders and chronic HIV disease in the antiretroviral therapy era: A systematic literature review
OBJECTIVES: Despite recent pharmacological progress, memory impairment is still frequently reported in people living with HIV. We aimed to conduct a systematic literature review investigating the presence of impairment of...
Assessment of neurocognitive deficits in people living with HIV in Sub Saharan Africa: A systematic review
Objective: People living with HIV (PLWH) are at risk for HIV-Associated Neurocognitive Disorders (HAND)/Neurocognitive Impairment (NCI). HIV prevalence in Sub-Saharan Africa (SSA) is high, but neuropsychological screening and testing for...
Optimal treatment of HIV-associated neurocognitive disorders: myths and reality. A critical review
Background: The aim of this study was to review the clinical data on the effectiveness of the pharmacotherapy of HIV-associated neurocognitive disorders (HANDs). Methods: A literature search of PubMed was...
In utero exposure to HIV and/or antiretroviral therapy: A systematic review of preclinical and clinical evidence of cognitive outcomes
INTRODUCION: With the increasing number of children exposed to HIV or antiretroviral therapy in utero, there are concerns that this population may have worse neurodevelopmental outcomes compared to those who...
