Category Archives: Mental Health
Differential genotypic evolution of HIV-1 quasispecies in cerebrospinal fluid and plasma: A systematic review
HIV-1 enters the central nervous system by passing the blood-brain barrier during primary infection. Despite the introduction of combination antiretroviral therapy, the prevalence of HIV-associated neurocognitive disorders remains high and...
The relationship between HIV and prevalence of disabilities in sub-Saharan Africa: Systematic review
OBJECTIVE: To systematically review evidence on the prevalence and risk of disabilities among children and adults living with HIV in sub-Saharan Africa. METHODS: Articles were identified from 1980 to June...
Experience of persistent psychological symptoms and perceived stigma among people with HIV on antiretroviral therapy (ART): A systematic review
BACKGROUND: Advances in HIV care have resulted in increasing numbers of HIV patients receiving antiretroviral therapy and achieving viral control. This has led to a focus on the biomedical aspects...
Gene expression in HIV-associated neurocognitive disorders: A meta-analysis
OBJECTIVES: To identify differentially expressed (DE) genes in HIV-associated neurocognitive disorders (HAND) patients in comparison with HIV-infected patients without HAND and controls. DESIGN: A meta-analysis of publicly available gene expression...
The syndemic illness of HIV and trauma: Implications for a trauma-informed model of care
BACKGROUND: People living with HIV infection are disproportionately burdened by trauma and the resultant negative health consequences, making the combination of HIV infection and trauma a syndemic illness. Despite the...
Substance abuse treatment in persons with HIV/AIDS: Challenges in managing triple diagnosis
Clinical management of HIV must account for the “triple diagnosis” of HIV, psychiatric diagnosis, and substance use disorders and requires integrated treatment services that focus beyond just mitigation of substance...
Depression and adherence to antiretroviral therapy in low-, middle- and high-income countries: A systematic review and meta-analysis
We investigated the associations between depressive symptoms and adherence to antiretroviral therapy (ART) among people living with HIV (PLHIV). We searched the PubMed, EMBASE and Cochrane CENTRAL databases for studies...
Targeting the SAVA (Substance Abuse, Violence, and AIDS) syndemic among women and girls: A global review of epidemiology and integrated interventions
OBJECTIVES: Multiple pathways link gender-based violence (GBV) to HIV and other sexually transmitted infections among women and girls who use or inject drugs. The aim of this article is to...
Meta-analysis of the relationship between HIV infection and risk for depressive disorders
Objective: Each of 10 published studies investigating the relationship between HIV infection and risk for depressive disorders concluded that HIV-positive individuais are at no greater risk for depression than comparable...
What is the evidence for effectiveness of interventions to enhance coping among people living with HIV disease? A systematic review
As new treatments enhance mortality, and infection rates continue to grow in many communities, the concept of “living well” with human immunodeficiency virus (HIV) infection is essential. The concept of...
Understanding HIV-related posttraumatic stress disorder in South Africa: A review and conceptual framework
A number of epidemiological studies have attempted to measure the prevalence of HIV-related posttraumatic stress disorder (PTSD) in sub-Saharan Africa. A systematic review of the literature identified eight relevant studies...
