Category Archives: Population(s)
Prevalence and determinants of virologic failure among HIV patients on ART in Africa: A systematic review and meta-analysis
Background The Joint United Nations Programme on HIV/AIDS (UNAIDS) has established the 95-95-95 targets, aiming that by 2030, 95% of individuals on ART will achieve viral suppression. While the number...
The safety of cabotegravir in pregnancy: A systematic review and meta-analysis
BACKGROUND: HIV remains an important global public health crisis. Antiretroviral treatment has been essential to suppress viral replication, and in at-risk individuals, antiretroviral pre-exposure prophylaxis drugs (PrEP) lower transmission rates....
Deep sequencing reveals underestimated burden of integrase inhibitor resistance mutations in people living with HIV: A global individual patient data meta-analysis
Integrase strand transfer inhibitors (INSTIs) have emerged as cornerstone agents in global antiretroviral therapy, though growing drug resistance presents clinical challenges. Conventional Sanger sequencing may underestimate the burden of low-frequency...
HIV testing among transgender and other gender-diverse persons in the United States: A scoping review
BACKGROUND: An overview of existing research on HIV testing among transgender and other gender-diverse (TGD) populations in the United States, critical for developing effective future interventions and research, is missing....
Wealth, income and HIV in sub-Saharan Africa: A systematic review
INTRODUCTION: While economic vulnerability is an established driver of health disparities, the relationships between HIV and wealth, income, and economic inequality have been less consistently established. We conducted a systematic...
Effect of same-day HIV treatment initiation (SDI) on 1-year outcomes in low- and middle-income countries: Systematic review and meta-analysis of randomised trials
Introduction Same-day initiation (SDI) of antiretroviral therapy is recommended for people presenting with HIV who have no contraindications. We reviewed the evidence on SDI interventions in low- and middle-income countries...
Efficacy of raltegravir in achieving virological suppression at delivery in HIV-positive pregnant women: A systematic review and meta-analysis
Background The world’s first HIV integrase inhibitor, raltegravir (RAL), has been widely used for the treatment of HIV infection over the past 15 years, and continues benefiting people living with...
Long-acting injectable cabotegravir and rilpivirine in observational cohort studies: A systematic review on virological failure, resistance and re-suppression outcomes in virally suppressed individuals living with HIV
Introduction Randomized controlled trial evidence suggests that long‐acting injectable (LA‐I) cabotegravir and rilpivirine (CAB+RPV) has similar virological failure (VF) rates to daily oral therapy, but clinical practice evidence is lacking....
Dolutegravir + lamivudine effectiveness and tolerability in real-world cohorts with HIV-1 across Asia and South America: A systematic literature review
Background: Dolutegravir (DTG) + lamivudine (3TC) has demonstrated efficacy and safety in phase 3 clinical trials; however, most published data are from people with HIV-1 in North America and Europe. Methods: To...
Gut microbiota of sub-Saharan Africa infants exposed to antiretroviral therapy: Scoping review
Background Antiretroviral (ARV) exposure influences the early-life gut microbiota in regions with high human immunodeficiency virus (HIV) burdens. Understanding how ARV drugs affect the infant gut microbiota is important for...
Evaluating the impact of COVID-19 on the HIV care continuum across global income levels: A mixed-methods systematic review
BACKGROUND: The COVID-19 pandemic caused significant disruptions to global healthcare systems, including essential services along the HIV care continuum (HCC). While several studies have examined these impacts in specific countries...
Psychosocial experience and coping of AIDS patients about the disease: A systematic review and qualitative meta-synthesis
AIM: To systematically integrate the psychosocial experiences and coping mechanisms of AIDS patients after the disease, and to understand their true feelings, in order to provide a basis for better...
