Category Archives: Population(s)

Efficacy and safety of triple versus dolutegravir-based dual therapy in patients with HIV-1 infection: A meta-analysis of randomized controlled trials

2021

A new strategy of simplification therapy shown the unique benefits in clinical treatment, by reducing pill burden and avoid drug exposure. To provide more evidence for the strategy, we compared...

HIV-1 capsid variability: Viral exploitation and evasion of capsid-binding molecules

2021

The HIV-1 capsid, a conical shell encasing viral nucleoprotein complexes, is involved in multiple post-entry processes during viral replication. Many host factors can directly bind to the HIV-1 capsid protein...

Significance of the placental barrier in antenatal viral infections

2021

The placenta provides a significant physical and physiological barrier to prevent fetal infection during pregnancy. Nevertheless, it is at times breached by pathogens and leads to vertical transmission of infection...

Global health facility-based interventions to achieve UNAIDS 90-90-90: A systematic review and narrative analysis

2021

To evaluate whether health facility-based HIV interventions align with UNAIDS 90-90-90 targets, we performed a systematic review through the lens of UNAIDS targets. We searched 11 databases, retrieving 5201 citations...

Important role of microglia in HIV-1 associated neurocognitive disorders and the molecular pathways implicated in its pathogenesis

2021

The development of effective combined anti-retroviral therapy (cART) led to a significant reduction in the death rate associated with human immunodeficiency virus type 1 (HIV-1) infection. However, recent studies indicate...

Long-acting reversible contraception, condom use, and sexually transmitted infections: A systematic review and meta-analysis

2021

Introduction Given mixed findings regarding the relationship between long-acting reversible contraception and condom use, this systematic review and meta-analysis synthesizes studies comparing sexually transmitted infection‒related outcomes between users of long-acting...

Academic detailing to increase prescribing of HIV pre-exposure prophylaxis

2021

Although HIV pre-exposure prophylaxis can decrease new cases of HIV by up to 99%, many patients who could benefit from pre-exposure prophylaxis never receive prescriptions for it. Because pre-exposure prophylaxis...

Gut microbiome in people living with HIV is associated with impaired thiamine and folate syntheses

2021

People living with HIV have a high incidence of cardiovascular and neurological diseases as comorbid disorders that are commonly linked to inflammation. While microbial translocation can augment inflammation during HIV...

Cardiovascular risk assessment in people living with HIV: A systematic review and meta-analysis of real-life data

2020

BACKGROUND: People living with HIV (PLWHIV) have a 2-fold higher risk of having a cardiovascular event than HIV-negative individuals. OBJECTIVE: The objective of this article is to estimate the pooled...

mHealth in the prevention of sexually transmitted infections STIs

2020

The objective of this study was to analyze in the literature how the applications were developed and how they influence the prevention of Sexually Transmitted Infections (STIs). PubMed, CAPES Periodicals...

Effectiveness of and best practices for using contingency management and incentives in hepatitis C infection among people who use drugs

2021

Using contingency management and incentives at the different steps of HIV care continuum (such as testing, treatment adherence, viral suppressions) is widely explored and discussed in the literature, whereas the...

Effectiveness of and best practices for using contingency management and incentives for health care issues related to HIV, sexually transmitted infections (STIs), and pre-exposure prophylaxis (PrEP)

2021

Using contingency management and incentives at the different steps of HIV care continuum (such as testing, treatment adherence, viral suppressions) is widely explored and discussed in the literature, whereas the...

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