Category Archives: Population(s)
Body composition, hepatic fat, metabolic, and safety outcomes of Tesamorelin, a GHRH analogue, in HIV-associated lipodystrophy: A meta-analysis of randomized controlled trials
BACKGROUND: HIV-associated lipodystrophy leads to visceral fat accumulation, metabolic complications, body image concerns, medication non-adherence, and increased cardiovascular risks. We thought to assess the effects of Tesamorelin, a synthetic growth...
Associations between Neuroimaging Measures and Cognitive Performance in Children, Adolescents, and Youth Living With HIV – a Systematic Review
PURPOSE OF REVIEW: Neurodevelopmental delays and neuroimaging abnormalities continue to be found in children, adolescents, and youth living with HIV despite the administration of effective combination antiretroviral therapy (cART). However,...
Comparing clinical outcomes of antibiotics for treating Mycobacterium avium complex infection in adults with HIV: A systematic review and network meta-analysis
BACKGROUND: This study aims to identify the comparative effects of different drug regimens in treating Mycobacterium avium complex (MAC). METHODS: PubMed, EMBASE, CENTRAL, and EBSCO Open Dissertations were searched in...
Systematic review and meta-analysis of respiratory virus infections in HIV-positive and HIV-negative patients
BACKGROUND: Respiratory virus infections are a major cause of morbidity and mortality globally, particularly among people living with HIV. OBJECTIVES: To evaluate the impact of respiratory virus infections on clinical...
Preferences for long-acting antiretroviral therapy among people with HIV: A systematic review of discrete choice experiments
BACKGROUND: Long-acting antiretroviral therapy (LA-ART) is emerging as a promising strategy to enhance treatment satisfaction and improve the quality of life for people living with HIV (PLWH). A comprehensive understanding...
Interventions to reduce HIV-related stigma among older people living with HIV in sub-Saharan Africa: a scoping review
HIV-related stigma remains a major barrier to testing, treatment, and quality of life, especially for the growing population of older people living with HIV (OPLWH, aged 50+). Such stigma intersects...
PrEP Delivery for US Adolescents and Young Adults: A Systematic Review and Narrative Synthesis
Despite proven efficacy in preventing human immunodeficiency virus (HIV) transmission, pre-exposure prophylaxis (PrEP) remains underutilized among adolescents and young adults (AYA) in the United States (US). This systematic review and...
Structural and socio-cultural barriers to HIV prevention tools among key populations: a scoping review
INTRODUCTION: Despite decades of HIV prevention efforts, key populations – MSM, transgender people, PWUD, sex workers, and migrants – remain disproportionately affected by HIV. Although prevention tools are widely available,...
Diagnostic accuracy of the WHO clinical staging system for detection of immunologically defined advanced HIV disease: A systematic review and meta-analysis
INTRODUCTION: People with advanced HIV disease face high risks of severe illness and death. CD4 testing enables timely diagnosis and appropriate care, yet access remains limited in many settings. This...
Pharmacogenetics in Tuberculosis-HIV Coinfected Populations: A Systematic Review of Genetic Variants Influencing Antiretroviral and Anti-Tuberculosis Drug Response
Pharmacogenetics is a concept designed to tailor medication based on genetic profile to improve efficacy and reduce adverse effects. This personalized strategy shows considerable potential for populations facing complicated therapeutic...
