Category Archives: Population(s)

Lenacapavir: A twice-yearly injectable for HIV preexposure prophylaxis

2025

OBJECTIVE: To review the efficacy and safety of lenacapavir for the prevention of HIV-1 infection. DATA SOURCES: Clinical trials and review articles were obtained through August 2025 using search terms...

High HIV viral suppression among adults receiving WHO-recommended first-line dolutegravir-based antiretroviral therapy in low- and middle-income countries: A systematic review and meta-analysis of programmatic evidence

2025

Background This systematic review and meta-analysis assessed viral suppression among adults receiving WHO-recommended first-line dolutegravir-based ART in programmatic settings in low- and middle-income countries (LMICs). Methods A systematic search of...

Oral pre-exposure prophylaxis retention among men who have sex with men and transgender persons: Systematic review and meta-analysis

2025

Successful implementation of oral pre-exposure prophylaxis (PrEP) requires retention in PrEP care among those with an increased likelihood of HIV. This study aimed to estimate the proportion of retention on...

Interventions to support breastfeeding among mothers living with HIV: A systematic review and meta-analysis of randomized controlled trials

2025

BACKGROUND: Breastfeeding improves infant survival, especially in low-resource settings. Although the risk of postnatal transmission is below 1% among virologically suppressed mothers living with HIV, exclusive breastfeeding (EBF) rates and...

Non-communicable disease burden among middle-aged and older adults living with HIV in the Western Pacific region: A systematic review and meta-analysis

2025

Objective: Middle-aged and older adults living with HIV in the Western Pacific Region (WPR) are experiencing accelerated aging and a rising burden of non-communicable disease (NCD)-related comorbidities. This systematic review and...

Antifungal resistance of Candida spp. isolates from HIV/AIDS patients in Iran 1999–2024: A systematic review and meta-analysis

2025

Background Antifungal resistance in Candida species in HIV/AIDS patients due to the scarcity of antifungal agents is important particularly in Iran with an estimate of 46,000 individuals living with HIV. This systematic...

Artificial intelligence for HIV care: A global systematic review of current studies and emerging trends

2025

INTRODUCTION: Artificial intelligence (AI) and, in particular, machine learning (ML) have emerged as transformative tools in HIV care, driving advancements in diagnostics, treatment monitoring and patient management. The present review...

Hepatitis C increases acute myocardial infarction risk in people living with HIV: A systematic review and meta-analysis

2025

BackgroundHepatitis C virus (HCV) coinfection is common among people living with HIV (PLWH) and is associated with adverse outcomes. However, the specific association between HCV coinfection and the risk of...

Performance of adherence measures for oral, tenofovir-based HIV pre-exposure prophylaxis: A systematic review

2025

Accurate adherence measures to HIV pre-exposure prophylaxis (PrEP) are essential for identifying individuals with low adherence and providing tailored support. This systematic review summarizes evidence on the performance of PrEP...

Assessing the effectiveness of Data-to-Care strategies for improving HIV care outcomes: A systematic review

2025

Data-to-Care (D2C) is a strategy that uses HIV surveillance data or other data sources to identify out-of-care (OOC) persons with HIV (PWH) and link or re-engage them in care to...

Deep vein thrombosis in adults with HIV: A systematic review and meta-analysis of prevalence and risk factors

2025

Deep vein thrombosis (DVT) is a preventable yet serious complication among people living with human immunodeficiency virus (PLWH), attributed to hypercoagulability, low CD4+ counts, and antiretroviral therapy. Despite the high...

Intermittent preventive treatment regimens for malaria in HIV-positive pregnant women: Systematic review and meta-analysis of clinical trials

2025

Background: The WHO recommended the use of intermittent preventive treatment (IPT) regimens for malaria in HIV-positive pregnant women living in endemic areas to prevent malaria-related perinatal complications. However, the high drug...

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