Category Archives: Population(s)
HIV, the gut microbiome and clinical outcomes, a systematic review
BACKGROUND: Effective antiretroviral therapy (ART) has improved the life expectancy of people with HIV (PWH). However, this population is now experiencing accelerated age-related comorbidities, contributed to by chronic immune activation...
Pre-exposure prophylaxis access, uptake and usage by young people: A systematic review of barriers and facilitators
BACKGROUND: Young people’s sexual health decision-making, including decisions to access and adhere to HIV prevention strategies such as Pre-Exposure Prophylaxis (PrEP), are influenced by a range of internal and external...
Opportunistic infections among schoolchildren who were on antiretroviral therapy in Ethiopia: A systematic review and meta-analysis
INTRODUCTION: The most common and severe cause of morbidity and mortality among HIV- positive children is opportunistic infections (OIs). All HIV-infected children are at risk of developing a variety of...
The impact of the COVID-19 pandemic on HIV healthcare delivery for females in sub-Saharan Africa: A scoping review
Throughout sub-Saharan Africa (SSA), females are disproportionately impacted by HIV and face generalized but also gendered social and economic barriers to accessing HIV healthcare and services. At the outset of...
Factors affecting poor prognosis of COVID-19 in people living with human immunodeficiency virus: A systematic review and meta-analysis of co-infection
Objectives: This study aims to assess the correlation between clinical features and mortality in human immunodeficiency virus (HIV)-infected individuals with COVID-19. Methods: A systematic literature search was conducted for cohort, cross-sectional, and...
Barriers and facilitators of HIV partner status notification in low- and lower-middle-income countries: A mixed-methods systematic review
BACKGROUND: The uptake of HIV partner status notification remains limited in low- and lower-middle-income countries. This mixed-methods systematic reviewAÿaims to summarize the barriers and facilitators of HIV partner status notification...
Thyroid disorders in patients with human immunodeficiency virus infection: A meta-analysis
Background Thyroid disorders have significant clinical sequelae, including impaired growth in children, metabolic abnormalities, and impaired cognitive function. However, available studies on burden of thyroid diseases in people with human...
Depressive symptoms and HIV viral suppression: A systematic review and meta-analysis
Previous research suggests that depression impacts HIV outcomes, including viral suppression. This meta-analysis quantifies the association between depression and HIV viral suppression. A systematic literature search was conducted in PubMed,...
Transitions in treatment: A systematic review and meta-aggregation of preferences and barriers in switching from oral to long-acting injectable antiretroviral therapy among people living with HIV and stakeholders
INTRODUCTION: Antiretroviral treatment (ART) has significantly enhanced health outcomes for people living with HIV (PLWH). With the evolution of treatment options, there is an increasing interest in the development of...
Neuropsychiatric outcomes in children and adolescents with perinatally acquired HIV: A systematic review and meta analysis
Objective: The objective of this study is to define the neuropsychiatric challenges including developmental delay, cognitive impairment, and psychiatric illness faced by children with perinatally acquired HIV. Data sources: Nine databases were...
Application of the COM-B model to facilitators and barriers to HIV and STI testing among people from Black African and Black Caribbean communities in the UK: A scoping review
OBJECTIVE: Individuals from Black African and Black Caribbean communities (black communities) in the UK bear a disproportionate burden of HIV and sexually transmitted infections (STIs), while exhibiting lower testing rates....
Comparative efficacy and safety of treatment regimens for Pneumocystis jirovecii pneumonia in people living with HIV: A systematic review and network meta-analysis of randomized controlled trials
BACKGROUND: Pneumocystis jirovecii pneumonia (PCP) is a serious opportunistic infection in people living with HIV (PWH) who have low CD4 counts. Despite its side effects, trimethoprim-sulfamethoxazole (TMP-SMX) is currently considered...
