Category Archives: Population(s)
HIV vaccination: Navigating the path to a transformative breakthrough-A review of current evidence
BACKGROUND AND AIM: Human immunodeficiency virus (HIV) remains a significant global health challenge, with approximately 39 million people living with HIV worldwide as of 2022. Despite progress in antiretroviral therapy,...
Efficacy and tollerability of INI-based 2-drug regimen in virosuppressed persons living with HIV: A systematic review and meta-analysis
BACKGROUND: The aim of this meta-analysis was to synthesize the available evidence from the literature on the efficacy and safety of integrase inhibitor-based two drug regimens compared to triple drug...
Retention in care among people living with HIV in Nigeria: A systematic review and meta-analysis
BACKGROUND: In 2021, Nigeria had an estimated 1.9 million people living with the human immunodeficiency virus (PLHIV) and 1.7 million (90%) on antiretroviral therapy (ART). Study Design: A systematic review...
Exploring facilitators and barriers to STD/STI/HIV self-testing among college students in the United States: A scoping review
Background: HIV affects 1.2 million Americans, with 20% of new diagnoses being 13 to 24-year-olds. Young adult college students are more likely than the general population of 18 to 24-year-olds in...
A systematic review and meta-analysis of the impact of the COVID-19 pandemic on access to HIV pre-exposure prophylaxis: Lessons for future public health crises
BACKGROUND: The World Health Organization is committed to strengthening access to pre-exposure prophylaxis (PrEP) for HIV prevention and its integration into primary care services. Unfortunately, the COVID-19 pandemic has disrupted...
Global, regional, and national prevalence of HIV-1 drug resistance in treatment-naive and treatment-experienced children and adolescents: A systematic review and meta-analysis
Background Despite significant reductions in mother-to-child HIV-1 transmission risks due to the advancements and scale-up of antiretroviral therapy (ART), the global burden of HIV-1 drug resistance (HIVDR) in treatment-naive and...
HIV prevention product acceptability and preference among women in Sub-Saharan Africa to inform novel biomedical options in development: A systematic review
The availability of several HIV prevention options may allow women to choose a product that suits their lifestyle and preferences. Product attributes and contextual factors influence product acceptability, which affects...
Population pharmacokinetic simulations for dose optimization of tenofovir disoproxil fumarate in HIV-infected patients with moderate-to-severe renal impairment
Tenofovir disoproxil fumarate (TDF) requires dosage adjustments from the standard 300 mg once daily to every 48–96 h for moderate-to-severe renal impairment to avoid excessive exposure. However, this extended interval...
Adverse perinatal outcomes associated with different classes of antiretroviral drugs in pregnant women living with HIV: A systematic review and meta-analysis
OBJECTIVE: Women living with HIV (WLHIV) are at increased risk of adverse perinatal outcomes compared to HIV-negative women, despite antiretroviral therapy (ART). There is evidence that the risk of adverse...
Influence factors associated with fertility intention among people living with HIV in China and other regions: A systematic review and meta-analysis
Background Advances in medical care and improved quality of life have fostered a growing desire for parenthood among people living with HIV (PLHIV). However, this desire remains inadequately addressed in...
Acceptability and use of HIV self-testing among young people in sub-Saharan Africa: A mixed methods systematic review
Background Young people (YP) are disproportionately affected by the HIV pandemic in sub-Saharan Africa (SSA), but testing rates remain low despite global targets of testing 95% of people with HIV...
