Category Archives: Population(s)
The burden of HIV-related stigma on clinical and quality of life outcomes: results from a systematic literature review
BACKGROUND: HIV-related stigma adversely impacts people with HIV. As part of a systematic literature review (SLR) to evaluate 6 research questions on HIV-related stigma among people with HIV, data from...
Structural competency as a global framework for syndemic HIV care: A critical synthesis
The co-occurrence of HIV with mental health disorders, substance use, and tuberculosis continues to constitute significant global public health issues. Syndemic theory elucidates how these conditions interact synergistically to exacerbate...
Peer-led models for improving HIV treatment and care outcomes among adolescents and young people living with HIV in eastern and southern Africa: A rapid review
Adolescents and Young People Living with HIV have poor levels of adherence to treatment and retention in care. Previous reviews highlighted the need for high-quality evidence on peer-led interventions for...
Optimising post-delivery viral load monitoring and HIV care to eliminate breastfeeding-associated HIV transmission in sub-Saharan Africa: A review
Sustained maternal HIV viral-load (VL) suppression during breastfeeding is essential for eliminating vertical HIV transmission in Sub-Saharan Africa. Although vertical transmission prevention programmes have improved antiretroviral therapy coverage and peripartum...
Determinants of cardiovascular disease risk among LGBTQ+ populations: A systematic review of empirical evidence
BACKGROUND: Understanding the multifactorial drivers of cardiovascular disease (CVD) risk in LGBTQ+ populations is critical to advancing equitable cardiovascular care. OBJECTIVE: To evaluate and synthesize empirical evidence on factors influencing...
The benefit of physical exercise in improving quality of life, VO(2) max and sleep quality among older adults living with HIV: A systematic review and meta-analysis
Background: Older adults living with HIV face multiple health challenges, yet evidence on the impact of exercise on their well-being remains limited. Regular physical activity is known to have multiple benefits...
Maternal, fetal, and neonatal outcomes of additional dihydroartemisinin-piperaquine to trimethoprim-sulfamethoxazole in intermittent preventive treatment for malaria in HIV-positive pregnancies: A systematic review and meta-analysis
PURPOSE: This systematic review evaluates the addition of Dihydroartemisinin-Piperaquine (DHA-PPQ) to Trimethoprim-Sulfamethoxazole (TMP-SMX) for Intermittent Preventive Treatment (IPT) in HIV-positive pregnancies, focusing on its effects on malaria infection, maternal adverse...
Artificial intelligence for predicting antiretroviral therapy outcomes in people living with HIV: A systematic review of predictive models, predictors and clinical readiness
BACKGROUND: Machine learning (ML), deep learning (DL) and other predictive modelling approaches are increasingly applied to predict antiretroviral therapy (ART) outcomes among people living with HIV, yet their methodological robustness...
Integrated service delivery models for triple elimination of mother to child transmission of human immunodeficiency virus, syphilis, and hepatitis B virus: A global systematic review and meta-analysis
BACKGROUND AND OBJECTIVES: Despite global commitment to the World Health Organization triple elimination initiative, evidence on integrated antenatal service delivery models that simultaneously address human immunodeficiency virus (HIV), syphilis, and...
The gut-immune axis in treated HIV infection: From mucosal damage to chronic inflammation and therapeutic opportunities—A clinician-oriented narrative review
Combined antiretroviral therapy (cART) has transformed HIV into a manageable chronic disease. However, people living with HIV (PLWH) experience a 16-year reduction in comorbidity-free life expectancy compared to HIV-negative individuals,...
Perspective of people living with HIV and healthcare workers on the uptake, barriers, and benefits of multimonth dispensing: A qualitative systematic review
INTRODUCTION: Multimonth dispensing (MMD) is a strategy in the HIV care continuum for people living with HIV (PLWH), especially for those who are virally suppressed. With the increase in MMD...
