Category Archives: Population(s)
Nevirapine or efavirenz combined with two nucleoside reverse transcriptase inhibitors compared to HAART: A meta-analysis of randomized clinical trials
Purpose: A meta-analysis of randomized controlled trials (RCTs) was performed to evaluate effectiveness and tolerability of triple antiretroviral therapy regimens in HIV-infected patients. Method: RCTs including the nonnucleoside reverse transcriptase...
Pneumocystis jirovecii pneumonia in tropical and low and middle income countries: A systematic review and meta-regression
OBJECTIVE: Pneumocystis jirovecii pneumonia (PCP), the commonest opportunistic infection in HIV-infected patients in the developed world, is less commonly described in tropical and low and middle income countries (LMIC). We...
Pharmacologic perspectives for once-daily antiretroviral therapy
OBJECTIVE: To contrast available once-daily antiretroviral agents and combinations of these agents from a clinical pharmacologic viewpoint. DATA SOURCES: Data were extracted from publications and major HIV conference proceedings cited...
Antiretroviral therapy in prevention of HIV and TB: Update on current research efforts
There is considerable scientific evidence supporting the use of antiretroviral therapy (ART) in prevention of human immunodeficiency virus (HIV) and tuberculosis (TB) infections. The complex nature of the HIV and...
Sexual risk reduction for HIV-infected persons: A meta-analytic review of “positive prevention” randomized clinical trials
BACKGROUND: Prevention intervention trials have been conducted to reduce risk of sexual transmission among people living with HIV/AIDS (PLWHA), but the findings were inconsistent. We performed a systematic review and...
Clinical trials in sub-Saharan Africa and established standards of care: A systematic review of HIV, tuberculosis, and malaria trials
Context: The minimum standard of care required for participants in clinical trials conducted in resource-poor settings is a matter of controversy; international documents offer contradictory guidance. Objective: To determine whether...
