Category Archives: Population(s)

Retention in care among people living with HIV in Nigeria: A systematic review and meta-analysis

2024

BACKGROUND: In 2021, Nigeria had an estimated 1.9 million people living with the human immunodeficiency virus (PLHIV) and 1.7 million (90%) on antiretroviral therapy (ART). Study Design: A systematic review...

Burden of tuberculosis in underserved populations in South Africa: A systematic review and meta-analysis

2024

Identifying case-finding strategies to reduce tuberculosis (TB) incidence in high-burden countries requires better knowledge of the disease burden in key contributing populations and settings. To inform South Africa’s National Tuberculosis...

Risk of dyslipidaemia in people living with HIV who are taking tenofovir alafenamide: a systematic review and meta-analysis

2024

INTRODUCTION: Among many antiretroviral drugs, tenofovir alafenamide is used extensively in combination regimens of tenofovir/emtricitabine or tenofovir/emtricitabine/bictegravir. However, concerns have arisen about the potential of tenofovir alafenamide to exacerbate hyperlipidaemia....

A scoping review of interventions targeting HIV stigma in women living with HIV

2024

Since its initial detection in the 1980s, AIDS has become a significant global health threat, disproportionately affecting women. Stigma constitutes the substantial barrier to accessing healthcare for women living with...

A systematic review and meta-analysis evaluating the effectiveness of minimally supervised home and community exercise interventions in improving physical activity, body adiposity and quality of life in adults living with HIV

2024

People living with HIV (PLWH) are physically inactive and risk cardiometabolic dysfunction. Home and community exercise (HCE) is pragmatic, cost-effective and improves health in varied chronic conditions. This review aimed...

Treatment failure among Sub-Sahara African children living with HIV: A systematic review and meta-analysis

2024

BACKGROUND: Antiretroviral treatment failure is a global issue, particularly in developing countries such as Sub-Saharan Africa. Prior research findings were highly variable and inconsistent across areas. As a result, the...

Pre-exposure Prophylaxis (PrEP) implementation among latino MSM: A qualitative scoping review of implementation determinants and change methods

2024

INTRODUCTION: The increasing rates of HIV among Latino men who have sex with men (MSM) necessitate innovative and rigorous studies to evaluate prevention and treatment strategies. Pre-exposure prophylaxis (PrEP) is...

Drug-drug interactions potential with the HIV-1 capsid inhibitor lenacapavir

2024

INTRODUCTION: Lenacapavir is the first HIV-1 capsid inhibitor administered subcutaneously twice yearly. While lenacapavir is currently only indicated as salvage therapy, it has the potential to become a foundation of...

Adverse perinatal outcomes associated with different classes of antiretroviral drugs in pregnant women living with HIV: A systematic review and meta-analysis

2024

OBJECTIVE: Women living with HIV (WLHIV) are at increased risk of adverse perinatal outcomes compared to HIV-negative women, despite antiretroviral therapy (ART). There is evidence that the risk of adverse...

Influence factors associated with fertility intention among people living with HIV in China and other regions: A systematic review and meta-analysis

2024

Background Advances in medical care and improved quality of life have fostered a growing desire for parenthood among people living with HIV (PLHIV). However, this desire remains inadequately addressed in...

Acceptability and use of HIV self-testing among young people in sub-Saharan Africa: A mixed methods systematic review

2024

Background Young people (YP) are disproportionately affected by the HIV pandemic in sub-Saharan Africa (SSA), but testing rates remain low despite global targets of testing 95% of people with HIV...

Vaginal microbiome and the risk of preterm birth in women living with HIV: A scoping review

2024

There are sparse data on the role of theAÿvaginal microbiome (VMB) in pregnancy among pregnant women living with HIV (PWLWH) and its association with spontaneous preterm birth (sPTB). We conducted...

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