Category Archives: Children or Youth (less than 18 years old)
Gut microbiota of sub-Saharan Africa infants exposed to antiretroviral therapy: Scoping review
Background Antiretroviral (ARV) exposure influences the early-life gut microbiota in regions with high human immunodeficiency virus (HIV) burdens. Understanding how ARV drugs affect the infant gut microbiota is important for...
Evidence-based interventions targeting mental health problems in adolescents living with HIV: A scoping review
Adolescents living with HIV are at an increased risk of experiencing mental health challenges, impacting their overall well-being and treatment adherence. Evidence-based interventions are crucial to addressing these issues; however,...
Mortality and associated factors among children with the double burden of human immunodeficiency virus and tuberculosis in African countries: A systematic review and meta-analysis
Introduction The dual burden of Human Immunodeficiency Virus (HIV) and Tuberculosis (TB) in children is leading to significant mortality. Although primary studies have reported wide ranges of mortality rates among...
Possible prevention of neurodevelopmental consequences of vertical HIV transmission in early childhood? A systematic review
BACKGROUND: Children infected with the Human Immunodeficiency Virus (HIV) exhibit the lowest neurodevelopmental scores. Mother-to-child-transmission prevention include perinatally and early antiretroviral therapy (ART) although long-term effects of in utero exposure...
Social determinants of adherence to antiretroviral therapy among adolescents and young people living with HIV: A scoping review
OBJECTIVE: To map scientific evidence related to social determinants of adherence to antiretroviral therapy among adolescents and young people living with HIV. METHOD: Scoping review according to JBI methodology, carried...
Incidence and predictors of attrition among children on antiretroviral therapy in Ethiopia: A systematic review and meta-analysis
Objective To estimate the pooled attrition rate among HIV-infected children receiving antiretroviral therapy (ART) and identify predictors of attrition in Ethiopia. Design Systematic review and meta-analysis. Data sources PubMed, HINARI,...
Determinants of HIV related mortality in African children on antiretroviral therapy: Clinical and immunological insights from a systematic review and meta-analysis
BACKGROUND: The HIV epidemic in Africa is still a serious public health concern, particularly for children who are more vulnerable to its negative consequences. Various studies carried out in different...
Prevalence and factors influencing HIV testing behavior in adolescents and young adults: A systematic review and meta-analysis
Objective To systematically evaluate the prevalence and influencing factors of human immunodeficiency virus (HIV) testing among adolescents and young adults (10–25 years old), providing a reference for optimizing testing strategies and...
HIV-related mortality time trends among children and young adolescents on antiretroviral therapy by age, treatment duration, and region: A systematic review and meta-regression analysis
Background: Past cohort studies have examined mortality among children and young adolescents (aged 0–14 years) who have received antiretroviral therapy (ART), but no systematic reviews have been undertaken to synthesise these...
Probability of vertical HIV transmission: A systematic review and meta-regression
Background Eliminating HIV vertical transmission is a global priority and monitored by estimating paediatric HIV infections with the UNAIDS-supported Spectrum AIDS Impact Module (Spectrum-AIM). Recent innovations in antiretroviral therapy (ART)...
Single-session interventions to enhance HIV outcomes among adolescents and young adults: A systematic scoping review and implications for integrating HIV and mental health services
Significant progress has been made in HIV prevention and treatment for adolescents and young adults (AYA), but integrating mental healthcare remains essential to address risks and improve treatment engagement. Single-session...
Mobile health intervention tools promoting HIV pre-exposure prophylaxis among adolescent girls and young women in sub-Saharan Africa: Scoping review
BACKGROUND: In 2022, 3100 adolescent girls and young women in sub-Saharan Africa experienced new HIV infections each week. HIV pre-exposure prophylaxis (PrEP) is effective at preventing HIV but has limited...
