Category Archives: Children or Youth (less than 18 years old)
Experiences and Outcomes of Peer Navigation and Support Interventions for Adolescents on HIV Treatment in Sub-Saharan Africa: A Qualitative Evidence Synthesis
Adolescents living with HIV (ALHIV) face ongoing challenges with treatment adherence and engagement in care, resulting in lower viral suppression rates compared to adults. Peer navigation has shown promise in...
A synthesis of dimensions of wellbeing among adolescents and young people living with HIV from Sub-Saharan Africa for measurement in economic evaluation: a qualitative overview of reviews
BACKGROUND: Adolescents and young people living with HIV (AYPLHIV) in sub-Saharan Africa (SSA) face intersecting structural and psychosocial challenges that compromise their wellbeing, yet these realities are poorly captured by...
Effects of transition from paediatric to adult HIV care on virological outcomes in sub-Saharan Africa: A systematic review and meta-analysis
BACKGROUND: HIV remains a major global burden, with 2.4 million children and adolescents affected, 84% living in sub-Saharan Africa. As adolescents age, transitioning from paediatric to adult HIV care represents...
Youth advisory board engagement in HIV research in low- and middle-income countries: a scoping review and additional youth perspectives
BACKGROUND: Engaging young people (10-24Aÿyears old) in research has been shown to improve the uptake and impact of HIV interventions in youth. However, how youth are engaged in Youth Advisory...
Prevention of mother-to-child transmission of HIV in the MENA region: A systematic review with comparative evidence from Sub-Saharan Africa
The Middle East and North Africa (MENA) region faces distinct challenges in addressing the HIV epidemic, including social stigma, limited surveillance data, and insufficient coverage of prevention services. Prevention of...
Factors influencing implementation of point-of-care tests for maternal and newborn screening and diagnosis in low-resource settings: a systematic review
BACKGROUND: Despite the potential of point-of-care (POC) tests to improve maternal and newborn health, implementation in low- and middle-income countries remains inconsistent. POC testing enables rapid, decentralized screening, but barriers...
The Gap in Integrated Pediatric Care: A Systematic Review of Family-Based Weight Management for Children Living with HIV
BACKGROUND: As children living with HIV (CWH) achieve longer life expectancy, they face an emerging ‘double burden’ of infectious and non-communicable diseases, specifically pediatric overweight and obesity (OW/OB). This risk...
Prevalence of HIV-associated nephropathy in children: a systematic review with meta-analysis of studies published between 2004 and 2019
INTRODUCTION: Despite major advances in antiretroviral therapy, HIV infection remains a significant global public health challenge. HIV can directly affect the kidneys, leading to HIV-associated nephropathy in children, a condition...
PrEP Delivery for U.S. Adolescents and Young Adults: A Systematic Review and Narrative Synthesis
Despite proven efficacy in preventing human immunodeficiency virus (HIV) transmission, pre-exposure prophylaxis (PrEP) remains underutilized among adolescents and young adults (AYA) in the United States (US). This systematic review and...
Effectiveness and safety of darunavir and lopinavir for treating children and adolescents living with HIV: a systematic review
INTRODUCTION: Darunavir and lopinavir solid formulations are recommended protease inhibitors for treating HIV. An evidence review of their effectiveness/efficacy and safety in young populations was needed to inform the 2025...
Understanding Antiretroviral Therapy Adherence in Children With HIV: A Review of Barriers and Strategies
INTRODUCTION: Despite advancements in antiretroviral therapy (ART) availability, maintaining optimal adherence remains difficult, especially in low- and middle-income countries (LMICs). This literature review synthesized evidence on barriers and interventions influencing...
