Category Archives: Children or Youth (less than 18 years old)
Tenofovir disoproxil fumarate safety for women and their infants during pregnancy and breastfeeding
OBJECTIVES: Pregnant/lactating women in some sub-Saharan Africa settings are at substantial risk of HIV acquisition and could benefit from preexposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF), but safety data...
Neurodevelopment in young children born to HIV-infected mothers: A meta-analysis
CONTEXT: HIV-infected (HIV+) children have worse neurodevelopmental outcomes compared with HIV-uninfected children. However, little is known regarding the differences in neurodevelopment between young HIV+ children, HIV-exposed but uninfected (HEU) children,...
Interventions to improve antiretroviral therapy adherence among adolescents in low- and middle-income countries: A systematic review of the literature
INTRODUCTION: Globally, an estimated 30% of new HIV infections occur among adolescents (15-24 years), most of whom reside in sub-Saharan Africa. Moreover, HIV-related mortality increased by 50% between 2005 and...
Implementation effectiveness of revised (post-2010) World Health Organization guidelines on prevention of mother-to-child transmission of HIV using routinely collected data in sub-Saharan Africa: A systematic literature review
BACKGROUND: To synthesize and evaluate the impact of implementing post-2010 World Health Organization (WHO) prevention of mother-to-child transmission (PMTCT) guidelines on attainment of PMTCT targets. METHODS: Retrospective and prospective cohort...
Improving retention in HIV care among adolescents and adults in low- and middle-income countries: A systematic review of the literature
INTRODUCTION: Adolescents living with HIV are an underserved population, with poor retention in HIV health care services and high mortality, who are in need of targeted effective interventions. We conducted...
Scaling a waterfall: A meta-ethnography of adolescent progression through the stages of HIV care in sub-Saharan Africa
INTRODUCTION: Observational studies have shown considerable attrition among adolescents living with HIV across the “cascade” of HIV care in sub-Saharan Africa, leading to higher mortality rates compared to HIV-infected adults...
Systematic review: A review of adolescent behavior change interventions [BCI] and their effectiveness in HIV and AIDS prevention in sub-Saharan Africa
BACKGROUND: Despite sub-Saharan Africa [SSA] constituting just 12% of the world’s population, the region has the highest burden of HIV with 70% of HIV infection in general and 80% of...
Antiretroviral therapy in HIV infected children with tuberculosis: A systematic review
BACKGROUND: Tuberculosis is the major cause of mortality in HIV-infected children globally. Current guidelines about the management of antiretroviral therapy in children with tuberculosis are based on a limited number...
Antiretroviral therapy for pregnant women living with HIV or hepatitis B: A systematic review and meta-analysis
OBJECTIVE: To assess the impact of various antiretroviral/antiviral regimens in pregnant women living with HIV or hepatitis B virus (HBV). DESIGN: We performed random effects meta-analysis for HIV-related outcomes and...
Vitamin A supplements for reducing mother-to-child HIV transmission
BACKGROUND: Strategies to reduce the risk of mother-to-child transmission of the human immunodeficiency virus (HIV) include lifelong antiretroviral therapy (ART) for HIV-positive women, exclusive breastfeeding from birth for six weeks...
Impact of SMS/GPRS printers in reducing time to early infant diagnosis compared to routine result reporting: A systematic review and meta-analysis
BACKGROUND: Despite significant gains made towards improving access, early infant diagnosis (EID) testing programs suffer from long test turnaround times that result in substantial loss to follow-up and mortality associated...
