Category Archives: Children or Youth (less than 18 years old)
Effective approaches for programming to reduce adolescent vulnerability to HIV infection, HIV risk, and HIV-related morbidity and mortality: A systematic review of systematic reviews
BACKGROUND: In 2012, an estimated 2.1 million adolescents were living with HIV. Though there are effective interventions to prevent and treat HIV infection, adolescents face specific barriers in accessing them....
Choice of antiretroviral drugs for postexposure prophylaxis for children: A systematic review
BACKGROUND: This systematic review aimed to assess the safety and efficacy of antiretroviral options for postexposure prophylaxis (PEP). Recognizing the limited data on the safety and efficacy of antiretroviral drugs...
The effectiveness of home-based HIV counseling and testing on reducing stigma and risky sexual behavior among adults and adolescents: A systematic review and meta-analyses
BACKGROUND: Human immunodeficiency virus counselling and testing is a critical and essential gateway to Human immunodeficiency virus prevention, treatment, care and support services. Though some primary studies indicate that home-based...
Factors underlying the success of behavioral HIV-prevention interventions for adolescents: a meta-review.
The purpose of this meta-review was to identify characteristics of successful HIV prevention interventions for adolescents based on quantitative (i.e., meta-analyses) and qualitative reviews published to date, and to inform...
Choice of antiretroviral drugs for postexposure prophylaxis for adults and adolescents: A systematic review
BACKGROUND: The choice of preferred regimens for human immunodeficiency virus postexposure prophylaxis (PEP) has evolved over the last 2 decades as more data have become available regarding the safety and...
Association between maternal HIV infection and low birth weight and prematurity: A meta-analysis of cohort studies
BACKGROUND: To assess the association between maternal human immunodeficiency virus (HIV) infection and low birth weight (LBW)/prematurity (PTD), we conducted a meta-analysis of cohort studies of HIV infected and uninfected...
Immunomodulatory effects of intravenous immunoglobulins (IVIGs) in HIV-1 disease: A systematic review
Intravenous immunoglobulins (IVIGs) are generally used as replacement therapy for humoral immunodeficiencies. In consideration of their immune-modulating properties, they are also employed as “immune-modulating/ anti-inflammatory” treatment in different clinical conditions....
Vitamin supplementation for prevention of mother-to-child transmission of HIV and pre-term delivery: A systematic review of randomized trial including more than 2800 women
Background: Observational studies have suggested that low serum vitamin levels are associated with increased mother-to-child transmission (MTCT) of HIV and increased preterm delivery. We aimed to determine the efficacy of...
Social support and HIV-related risk behaviors: A systematic review of the global literature
Existing empirical evidence has well documented the role of social support in both physical and psychological well-being among various populations. In the context of HIV prevention, the rapid increase of...
Improved access to early infant diagnosis is a critical part of a child-centric prevention of mother-to-child transmission agenda
BACKGROUND: Prevention-of-mother-to-child-transmission (PMTCT) programs have made it possible to achieve dramatic reductions in the rate of vertical HIV transmission. However, high attrition, particularly after delivery, has limited the impact of...
Effect of cotrimoxazole on mortality in HIV-infected adults on antiretroviral therapy: A systematic review and meta-analysis
OBJECTIVE: To determine whether cotrimoxazole reduces mortality in adults receiving antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection in low- and middle-income countries through a systematic review and meta-analysis....
