Category Archives: Children or Youth (less than 18 years old)
Boosted protease inhibitors as a therapeutic option in the treatment of HIV-infected children
OBJECTIVE: Paediatric HIV treatment must address various special considerations. Administration of pharmacokinetically enhanced protease inhibitors (PIs) can improve paediatric therapeutic outcomes. The objective of this study was to review the...
Lessons learned from family-centred models of treatment for children living with HIV: Current approaches and future directions
BACKGROUND: Despite strong global interest in family-centred HIV care models, no reviews exist that detail the current approaches to family-centred care and their impact on the health of children with...
Unit costs for delivery of antiretroviral treatment and prevention of mother-to-child transmission of HIV: A systematic review for low- and middle-income countries
As antiretroviral treatment (ART) for HIV/AIDS is scaled up globally, information on per-person costs is critical to improve efficiency in service delivery and to maximize coverage and health impact. The...
High mortality amongst adolescents and adults with bacterial meningitis in sub-Saharan Africa: An analysis of 715 cases from Malawi
Mortality from bacterial meningitis in African adults is significantly higher than those in better resourced settings and adjunctive therapeutic interventions such as dexamethasone and glycerol have been shown to be...
Interventions for the prevention of mycobacterium avium complex in adults and children with HIV
BACKGROUND: Mycobacterium avium complex (MAC) infection is a common complication of advanced acquired immunodeficiency syndrome (AIDS) disease and is an independent predictor of mortality and shortened survival. OBJECTIVES: To determine...
Effectiveness of HIV prevention for youth in sub-Saharan Africa: Systematic review and meta-analysis of randomized and nonrandomized trials
Objective: Systematically assess the effectiveness of HIV-prevention interventions in changing sexual behaviour of young people (10-25 years) in sub-Saharan Africa. Methods: Three online databases were searched using prespecified terms. Additional...
School-based teenage pregnancy prevention programs: A systematic review of randomized controlled trials
We compared school-based abstinence-only programs with those including contraceptive information (abstinence-plus) to determine which has the greatest impact on teen pregnancy. The United States has one of the highest rates...
Patient support and education for promoting adherence to highly active antiretroviral therapy for HIV/AIDS
Background: Adherence to prescribed regimens is required to derive maximal benefit from many highly active antiretroviral therapy (HAART) regimens in people living with HIV/AIDS.Objectives: To conduct a systematic review of...
Corticosteroid administration and outcome of adolescents and adults with acute bacterial meningitis: A meta-analysis
OBJECTIVE: To systematically assess the effect of the adjunctive administration of corticosteroids in the treatment of acute bacterial meningitis. METHODS: We performed a systematic review and meta-analysis by searching several...
Improving the prevention, diagnosis and treatment of TB among people living with HIV: The role of operational research
Operational research is necessary to improve the access to and delivery of tuberculosis prevention, diagnosis and treatment interventions for people living with HIV. We conducted an extensive review of the...
Post-HAART outcomes in pediatric populations: Comparison of resource-limited and developed countries
CONTEXT: No formal comparison has been made between the pediatric post-highly active antiretroviral therapy (HAART) outcomes of resource-limited and developed countries. OBJECTIVE: To systematically quantify and compare major baseline characteristics...
