Category Archives: People who use drugs

Strategies to Improve PrEP Adherence in People Who Use Drugs: A Systematic Review

2026

People who use drugs (PWUD) face a disproportionately high risk of HIV, accounting for a considerable share of cases in the United States. Pre-exposure prophylaxis (PrEP) has been shown to...

Interventions to Improve HIV Care and Treatment Outcomes Among People with HIV Who Have Substance Use Disorder or At-Risk Substance Use: A Narrative Review

2026

Substance use adversely affects engagement in HIV care, adherence to medication, and HIV viral suppression. This review assessed the scope of US interventions designed to promote positive outcomes along the...

Harm reduction progams and interventions for equity-deserving populations who use crack-cocaine. A scoping review

2026

BACKGROUND: Crack-cocaine use is associated with severe physical and mental health consequences, including cardiac, pulmonary and psychiatric conditions. It also heightens the risk of overdose and transmission of infectious diseases...

Structural and socio-cultural barriers to HIV prevention tools among key populations: A scoping review

2025

INTRODUCTION: Despite decades of HIV prevention efforts, key populations – MSM, transgender people, PWUD, sex workers, and migrants – remain disproportionately affected by HIV. Although prevention tools are widely available,...

Effectiveness of telehealth in HIV management for people living with HIV and key populations: A systematic review of models, adherence, viral suppression, and behavioral outcomes

2026

Human Immunodeficiency Virus (HIV) is a global health problem that causes many deaths, especially in low- and middle-income countries (LMICs). Most HIV cases occur in sub-Saharan Africa and Asia. In...

Risk prediction models for targeted testing of HIV, hepatitis B and hepatitis C: A systematic review and meta-analysis

2025

Background Diagnosing human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV) infections in general population settings is challenging. We conducted a systematic review and meta-analysis of...

Contextual and culturally adapted interventions to improve HIV outcomes: A scoping review

2025

BACKGROUND: Antiretroviral therapy is widely available, yet structural, social, and cultural barriers still limit human immunodeficiency virus prevention and care. Prevention tools such as consistent condom use and pre-exposure prophylaxis...

Promoting healthy aging through mindfulness and yoga: A systematic review of interventions for people living with HIV who use drugs or who have a history of substance use

2025

Advances in HIV care and broader access to antiretroviral therapy (ART) have extended life expectancy for people living with HIV, yet aging-related health concerns, especially among those who use substances,...

Risk of hepatitis C virus reinfection after direct-acting antiviral treatment among HIV-positive men who have sex with men and people who inject drugs: A systematic review and meta-analysis

2025

The incidence of hepatitis C virus (HCV) reinfection following successful direct-acting antiviral therapy in HIV/HCV co-infected individuals remains a significant public health concern. This study aimed to estimate the reinfection...

Evolving landscape of economic evaluations of HIV pre-exposure prophylaxis and pre-exposure prophylaxis implementation strategies: A systematic review

2025

INTRODUCTION: Economic evaluations of HIV pre-exposure prophylaxis (PrEP) and associated implementation strategies guide evidence-based policies, programmes and resource allocation. Since 2015, there has been an evolution in PrEP modalities, implementation...

Cost-effectiveness of HIV prevention strategies: A systematic review of economic evaluations

2025

BACKGROUND: HIV/AIDS continues to pose a significant global health challenge, especially in low- and middle-income countries. Economic evaluations are essential to identify cost-effective prevention strategies and allocate limited healthcare resources...

Minority stress and stimulant use among US adult sexual minority men: A systematic review

2025

Purpose Minority stress theory posits health disparities among sexual minority men (SMM; i.e., non-heterosexual) result from experiences of sexual minority stigma (SMS). This systematic review synthesizes quantitative findings on the...

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