Category Archives: General HIV+ population
Reviews on HIV+ people where the population is not specified
The role of coinfections in HIV epidemic trajectory and positive prevention: A systematic review and meta-analysis
OBJECTIVES: Recurrent or persistent coinfections may increase HIV viral load and, consequently, risk of HIV transmission, thus increasing HIV incidence. We evaluated the association between malaria, herpes simplex virus type...
Deworming helminth co-infected individuals for delaying HIV disease progression
BACKGROUND: The HIV-1 pandemic has disproportionately affected individuals in resource-constrained settings. These areas often also have high prevalence of other infectious diseases, such as helminth infections. It is important to...
Stavudine, lamivudine and nevirapine combination therapy for treatment of HIV infection and AIDS in adults
BACKGROUND: A favourable regimen for people infected with HIV/AIDS is one that provides optimal efficacy, durability of antiretroviral activity, tolerability, and has low adverse effects and drug-drug interactions. The combination...
The effects of dietary intervention on HIV dyslipidaemia: A systematic review and meta-analysis
Background: Efficacy of dietary intervention for treatment and prevention of HIV-related lipid disturbances has not been well established. Methods: We conducted a systematic search of electronic databases supplemented with manual...
How much ritonavir is needed to boost protease inhibitors? Systematic review of 17 dose-ranging pharmacokinetic trials
BACKGROUND: Ritonavir has been evaluated at boosting doses of 50–800 mg daily with seven protease inhibitors: amprenavir, atazanavir, darunavir, indinavir, lopinavir,saquinavir and tipranavir. Minimizing the boosting dose of ritonavir could...
Posaconazole for the treatment of oropharyngeal candidiasis, including triazole-resistant disease, in HIV-positive patients
Oropharyngeal candidiasis is a common affliction in HIV-positive patients worldwide. Although the incidence has decreased with the advent of potent antiviral combinations, it continues to be a cause of significant...
Corticosteroid administration and outcome of adolescents and adults with acute bacterial meningitis: A meta-analysis
OBJECTIVE: To systematically assess the effect of the adjunctive administration of corticosteroids in the treatment of acute bacterial meningitis. METHODS: We performed a systematic review and meta-analysis by searching several...
Efficacy and tolerability of initial antiretroviral therapy: A systematic review
OBJECTIVES: Successful antiretroviral therapy (ART) is largely attributed to the type of third drug. Guidelines recommend regimens without systematic review of all factors that might affect treatment success, such as...
Rifamycins (rifampicin, rifabutin and rifapentine) compared to isoniazid for preventing tuberculosis in HIV-negative people at risk of active TB
Background: Preventing active tuberculosis (TB) from developing in people with latent tuberculosis infection (LTBI) is important for global TB control. Isoniazid (INH) for six to nine months has 60% to...
Peginterferon plus ribavirin for chronic hepatitis C in patients with human immunodeficiency virus
OBJECTIVES: The aim of this study was to assess the effects of peginterferon plus ribavirin for chronic hepatitis C in patients with human immunodeficiency virus (HIV). METHODS: Trials were identified...
Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa
Two-thirds of the world’s HIV-infected people live in sub-Saharan Africa, and more than 1.5 million of them die annually. As access to antiretroviral treatment has expanded within the region; early...
